Gender-Specific Differences in Gut Microbiota Composition Associated with Microbial Metabolites for Patients with Acne Vulgaris

Huang Yukun; Liu Lu; Chen Linna; Zhou Lin; Xiong Xia; Deng Yongqiong

doi:10.5021/ad.2021.33.6.531

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자료유형: 학술저널

저자정보: Huang Yukun (Affiliated Hospital of Southwest Medical University) Liu Lu (Affiliated Hospital of Southwest Medical University) Chen Linna (Affiliated Hospital of Southwest Medical University) Zhou Lin (Affiliated Hospital of Southwest Medical University) Xiong Xia (Affiliated Hospital of Southwest Medical University) Deng Yongqiong (Affiliated Hospital of Southwest Medical University)

저널정보: 대한피부과학회 Annals of Dermatology Annals of Dermatology 제33권 제6호

발행연도: 2021.12

수록면: 531 - 540 (10page)

DOI: 10.5021/ad.2021.33.6.531

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Background: The gut microbial dysbiosis and gender differences in the pathogenesis of acne vulgaris have long been postulated respectively. However, there was no data about a gender- related discrepancy in gut microbiota and microbial metabolism in acne. Objective: This study aimed at identifying the underlying gender-related difference in gut mi- crobiota and metabolism in acne vulgaris. Methods: Fecal samples were collected from 43 acne patients and 43 age and gender-matched controls. Gut microbiota was analyzed by sequencingthe V3-V4 regionof gene and microbial metabolites were quantitatively detected using gas chromatography time-of-flight mass spectrometry. Results: Compared with healthy controls, the men had a lower abundance of 18 microbes such as Butyricicoccus Clostridium sensu stricto Faecalibaculum Bacillus Lactococcus Blautia Clostridiales Lachnospiracea incertae sedis Ruminococcus at genus level. However, the female patients only showed increased Clostridium sensu stricto and declined Oscilli-bacter Odoribacterin. Additionally, the disordered metabolism of fatty acids was identi- fied in male patients, while the dysbiosis of amino acids metabolism in female ones.Conclusion: The disorder of gut microbiota and metabolism in acne vulgaris was gender- specific, which supported the potential role of gender difference in the pathogenesis of this disease.

#Acne vulgaris #Gastrointestinal microbiome #Gender differences #Metabolites

참고문헌 (42)

참고문헌 신청

Bhate K / 2013 / Epidemiology of acne vulgaris / Br J Dermatol 168:474~485

Kubota Y / 2010 / Community-based epidemiological study of psychosocial effects of acne in Japanese adolescents / J Dermatol 37:617~622

Cook-Bolden FE / 2020 / Tazarotene 0.045% lotion for the once-daily treatment of moderate-to-severe acne vulgaris in adult males / J Drugs Dermatol 19:78~85

Sugawara T / 2019 / Gender- and age-related differences in facial sebaceous glands in Asian skin, as observed by non-invasive analysis using three-dimensional ultrasound microscopy / Skin Res Technol 25:347~354

Demirkan S / 2019 / CAG polymorphism in the androgen receptor gene in women may be associated with nodulocystic acne / Postepy Dermatol Alergol 36:173~176

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