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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제15권 제3호
- 발행연도
- 2017.8
- 수록면
- 222 - 228 (7page)
- DOI
- https://doi.org/10.9758/cpn.2017.15.3.222
이용수
초록· 키워드
오류제보하기
Objective: This study aimed to investigate the association between the synaptosomal-associated protein 25 kDa (SNAP-25) genotype and performance on the continuous performance test (CPT) in Korean children with attention-deficit/hyperactivity disorder (ADHD).
Methods: Eighty-seven children with ADHD (mean age, 9.23±1.99 years) participated in this study. Omission errors, commission errors, reaction time, and reaction time variability on the CPT were analyzed. The single-nucleotide polymorphism (SNP) rs3746544 (1065 T＞G) of SNAP-25 was genotyped to examine the association with CPT performance.
Results: We found significantly more omission errors on the CPT among children with the TT genotype of SNAP-25 (t=2.56, p=0.012) after correcting for multiple testing.
Conclusion: Our results suggest the possible involvement of the SNAP-25 1065 T＞G polymorphism in the inattention phenotype in children with ADHD. Further studies with more refined neuropsychological measures and much larger sample sizes are needed to confirm our findings.
목차
등록된 정보가 없습니다.
참고문헌 (48)
참고문헌 신청
Biederman J / 2005 / Attention-deficit hyperactivity disorder / Lancet 366:237~248
Faraone SV / 2005 / Molecular genetics of attentiondeficit/hyperactivity disorder / Biol Psychiatry 57:1313~1323
Heiser P / 2004 / Molecular genetic aspects of attentiondeficit/hyperactivity disorder / Neurosci Biobehav Rev 28:625~641
Doyle AE / 2005 / Are endophenotypes based on measures of executive functions useful for molecular genetic studies of ADHD? / J Child Psychol Psychiatry 46:774~803
Doyle AE / 2005 / Attention-deficit/hyperactivity disorder endophenotypes / Biol Psychiatry 57:1324~1335
Faraone SV / 2005 / Molecular genetics of attentiondeficit/hyperactivity disorder / Biol Psychiatry 57:1313~1323
Heiser P / 2004 / Molecular genetic aspects of attentiondeficit/hyperactivity disorder / Neurosci Biobehav Rev 28:625~641
Doyle AE / 2005 / Are endophenotypes based on measures of executive functions useful for molecular genetic studies of ADHD? / J Child Psychol Psychiatry 46:774~803
Doyle AE / 2005 / Attention-deficit/hyperactivity disorder endophenotypes / Biol Psychiatry 57:1324~1335
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