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논문 기본 정보

자료유형
학술저널
저자정보
Chia-Ling Yu (Department of Pharmacy Chang-Gung Memorial Hospital) Fu-Chi Yang (Department of Neurology Tri-Service General Hospital National Defense Medical Center) Szu-Nian Yang (Department of Psychiatry Beitou Branch Tri-Service General Hospital National Defense Medical Center) Ping-Tao Tseng (WinShine Clinics in Specialty of Psychiatry) Brendon Stubbs (Physiotherapy Department South London and Maudsley NHS Foundation Trust) Ta-Chuan Yeh (Department of Psychiatry Tri-Service General Hospital National Defense Medical Center) Chih-Wei Hsu (Department of Psychiatry Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College o) Dian-Jeng Li (Department of Addiction Science Kaohsiung Municipal Kai-Syuan Psychiatric Hospital) Chih-Sung Liang (Graduate Institute of Medical Sciences National Defense Medical Center)
저널정보
대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION 제18권 제10호
발행연도
2021.10
수록면
958 - 967 (10page)
DOI
10.30773/pi.2021.0209

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Objective To systematically examine the effectiveness and tolerability of psilocybin for treating end-of-life anxiety symptoms.Methods The Medline, Embase, CENTRAL, and PsycINFO databases were searched up to November 25, 2020. We enrolled clinical trials investigating psilocybin for treating end-of-life anxiety symptoms. Meta-analysis was conducted using random-effects model.Results Overall, five studies were included, revealing that psilocybin was superior to the placebo in treating state anxiety at 1 day (Hedges’ g, -0.70; 95% confidence interval, -1.01 to -0.39) and 2 weeks (-1.03; -1.47 to -0.60) after treatment. Psilocybin was more effective than placebo in treating trait anxiety at 1 day (-0.71; -1.15 to -0.26), 2 weeks (-1.08; -1.80 to -0.36), and 6 months (-0.84; -1.37 to -0.30) after treatment. Psilocybin was associated with transient elevation in systolic (19.00; 13.58?24.41 mm Hg) and diastolic (8.66; 5.18?12.15 mm Hg) blood pressure compared with placebo. The differences between psilocybin and placebo groups with regard to allcause discontinuation, serious adverse events, and heart rates were nonsignificant.Conclusion Psilocybin-assisted therapy could ameliorate end-of-life anxiety symptoms without serious adverse events. Because of the small sample sizes of the included studies and high heterogeneity on long-term outcomes, future randomized controlled trials with large sample sizes are needed.
#Psilocybin #End-of-life anxiety #Life-threatening disease #Meta-analysis #Cancer.

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참고문헌 (45)

참고문헌 신청
Antoni MH / 2013 / Psychosocial intervention effects on adaptation, disease course and biobehavioral processes in cancer / Brain Behav Immun 30(Suppl):S88~S98 google schola Gil F / 2012 / First anxiety, afterwards depression : psychological distress in cancer patients at diagnosis and after medical treatment / Stress Health 28:362~367 google schola Linden W / 2012 / Anxiety and depression after cancer diagnosis : prevalence rates by cancer type, gender, and age / J Affect Disord 141:343~351 google schola Perez MN / 2020 / Barriers to care in pediatric cancer : the role of illness uncertainty in relation to parent psychological distress / Psychooncology 29:304~310 google schola Vander Haegen M / 2018 / Intolerance of uncertainty in parents of childhood cancer survivors : a clinical profile analysis / J Psychosoc Oncol 36:717~733 google schola

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