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논문 기본 정보

자료유형
학술저널
저자정보
Seungmin Kim (건국대학교) 이형우 (건국대학교) Hyewon Chung (건국대학교) 김형찬 (건국대학교)
저널정보
대한안과학회 Korean Journal of Ophthalmology Korean Journal of Ophthalmology 제35권 제5호
발행연도
2021.10
수록면
397 - 409 (13page)
DOI
10.3341/kjo.2021.0085

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Purpose: The present study aimed to quantify various factors of vessel morphology, including vessel diameter, length, andcomplexity (fractal dimension and lacunarity) of both choroidal neovascularization (CNV) and en face Haller vessels using opticalcoherence tomography angiography (OCTA) and en face structural optical coherence tomography in typical neovascularage-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) and to identify factors associatedwith visual acuity (VA) loss and number of injections within a year after the day of OCTA. Methods: We retrospectively analyzed 43 eyes of nAMD patients and 33 eyes of PCV patients whose OCTA was performedat least 12 months after an initial anti-vascular endothelial growth factor treatment. Quantitative parameters, including vesselarea, vessel diameter, vessel length, fractal dimension, and lacunarity were analyzed from en face images of CNV andHaller vessels. Clinical information, including logarithm of the minimum angle of resolution visual acuity and injection numberof anti-vascular endothelial growth factor were acquired after 12 months from OCTA date. Using logistic regression analyses,parameters associated with logarithm of the minimum angle of resolution VA loss of 0.2 or more (VA loss group) and a numberof injections of four or more (unstable group) after 12 months were analyzed. Results: In typical nAMD, the VA loss group was associated with a smaller number of intersections of Haller vessels. The unstablegroup was associated with an increased lacunarity of CNV in typical nAMD. In PCV, both VA loss and unstable groupswere associated with a higher maximal diameter of Haller vessels. Conclusions: VA loss and injection number of nAMD and PCV 12 months after OCTA imaging were associated with differentmorphological parameters of CNV and Haller vessels. Therefore, quantitative analyses of both CNV and Haller vessels fromOCTA and en face optical coherence tomography might provide prognostic information about visual outcome and injectionfrequency within 12 months after OCTA imaging.

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