Interplay Between Cognitive and Bowel/Bladder Function in Multiple Sclerosis

Antonio Carotenuto; Teresa Costabile; Marcello Moccia; Fabrizia Falco; Maria Petracca; Barbara Satelliti; Cinzia Valeria Russo; Francesco Saccà; Roberta Lanzillo; Vincenzo Brescia Morra

doi:10.5213/inj.2040346.173

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저자정보: Antonio Carotenuto (Department of Neurosciences Reproductive and Odontostomatological Sciences ‘Federico II’ Universit) Teresa Costabile (Department of Neurosciences Reproductive and Odontostomatological Sciences ‘Federico II’ Universit) Marcello Moccia (Department of Neurosciences Reproductive and Odontostomatological Sciences ‘Federico II’ Universit) Fabrizia Falco (Department of Neurosciences Reproductive and Odontostomatological Sciences ‘Federico II’ Universit) Maria Petracca (Department of Neurosciences Reproductive and Odontostomatological Sciences ‘Federico II’ Universit) Barbara Satelliti (Department of Neurosciences Reproductive and Odontostomatological Sciences ‘Federico II’ Universit) Cinzia Valeria Russo (Department of Neurosciences Reproductive and Odontostomatological Sciences ‘Federico II’ Universit) Francesco Saccà (Department of Neurosciences Reproductive and Odontostomatological Sciences ‘Federico II’ Universit) Roberta Lanzillo (Department of Neurosciences Reproductive and Odontostomatological Sciences ‘Federico II’ Universit) Vincenzo Brescia Morra (Department of Neurosciences Reproductive and Odontostomatological Sciences ‘Federico II’ Universit)

저널정보: 대한배뇨장애요실금학회 International Neurourology Journal International Neurourology Journal 제25권 제4호

발행연도: 2021.12

수록면: 310 - 318 (9page)

DOI: 10.5213/inj.2040346.173

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Purpose: The aim of this study was to evaluate the prevalence of bowel/bladder dysfunction in multiple sclerosis (MS) and its associations with cognitive impairment. Methods: We prospectively enrolled 150 MS patients. Patients were administered the Symbol Digit Modality Test (SDMT), the Neurogenic Bowel Dysfunction Score (NBDS), and the Actionable Bladder Symptom Screening Tool (ABSST). The associations between bowel/bladder dysfunction and cognitive function were assessed through hierarchical regression models using the SDMT and clinicodemographic features as independent variables and NBDS and ABSST scores as dependent variables. Results: The prevalence of bowel/bladder deficits was 44.7%, with 26 patients (17.3%) suffering from bowel deficits and 60 patients (40%) from bladder deficits. The total NBDS and ABSST scores were correlated with the SDMT (β=-0.10, P<0.001 and β=-0.03, P=0.04, respectively) after correction for demographic features and physical disability. Conclusions: Bowel/bladder disorders are common in MS and are associated with both physical and cognitive disability burdens. As SDMT is embedded into routine clinical assessments, a lower score may warrant investigating bowel/bladder dysfunction due to the strong interplay of these factors.

#Bowel #Bladder #Cognition #Disability #Patient-Reported Outcome

참고문헌 (35)

참고문헌 신청

Ochoa-Morales A / 2019 / Quality of life in patients with multiple sclerosis and its association with depressive symptoms and physical disability / Mult Scler Relat Disord 36:101386

Filippi M / 2018 / Multiple sclerosis / Nat Rev Dis Primers 4:43

Litwiller SE / 1999 / Multiple sclerosis and the urologist / J Urol 161:743~757

Thiruppathy K / 2014 / Multiple sclerosis related bowel dysfunction: pathophysiology, clinical manifestation and management / J Neurol Neurophysiol 5:6

Nortvedt MW / 2001 / Reduced quality of life among multiple sclerosis patients with sexual disturbance and bladder dysfunction / Mult Scler 7:231~235

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