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논문 기본 정보

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저자정보
Martina Aida Angeles (Institut Universitaire du Cancer de Toulouse - Institut Claudius Regaud) Bastien Cabarrou (Institut Universitaire du Cancer de Toulouse Oncopole (IUCT- Oncopole)) Antonio Gil-Moreno (Gynecologic Oncology Unit Vall d'Hebron University Hospital Barcelona Spain) Asunción Pérez-Benavente (Hospital Universitari Vall d'Hebron) Emanuela Spagnolo (Department of Gynecology “La Paz” University Hospital Madrid Spain) Agnieszka Rychlik (Maria Skłodowska-Curie National Research Institute of Oncology) Carlos Martínez-Gómez (Institut Claudius Regaud Institut Universitaire du Cancer de Toulouse Oncopole (IUCT-Oncopole)) Frédéric Guyon (Department of Surgical Oncology Institut Bergonié Bordeaux France) Ignacio Zapardiel (La Paz University Hospital) Denis Querleu (Honorary Professor of the University of Toulouse France) Claire Illac (Institut Universitaire du Cancer de Toulouse Oncopole (IUCT-Oncopole)) Federico Migliorelli (Centre Hospitalier Intercommunal des Vallées de l'Ariège) Sarah Bétrian (Institut Claudius Regaud Institut Universitaire du Cancer de Toulouse Oncopole (IUCT-Oncopole)) Gwénaël Ferron (Inserm CRCT Toulouse France) Alicia Hernández (Hospital Universitario La Paz) Alejandra Martinez (Inserm CRCT Toulouse France)
저널정보
대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.32 No.6
발행연도
2021.11
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1 - 13 (13page)
DOI
https://doi.org/10.3802/jgo.2021.32.e78

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Objective: We sought to evaluate the impact on survival of tumor burden and surgical complexity in relation to the number of cycles of neoadjuvant chemotherapy (NACT) in patients with advanced ovarian cancer (OC) with minimal (CC-1) or no residual disease (CC-0). Methods: This retrospective study included patients with International Federation of Gynaecology and Obstetrics IIIC?IV stage OC who underwent debulking surgery at 4 high- volume institutions between January 2008 and December 2015. We assessed the overall survival (OS) of primary debulking surgery (PDS group), early interval debulking surgery after 3?4 cycles of NACT (early IDS group) and delayed debulking surgery after 6 cycles (DDS group) with CC-0 or CC-1 according to peritoneal cancer index (PCI) and Aletti score. Results: Five hundred forty-nine women were included: 175 (31.9%) had PDS, 224 (40.8%) early IDS and 150 (27.3%) DDS. Regardless of Aletti score, median OS after PDS was significantly higher than after early IDS or DDS, but the survival difference was higher in women with an Aletti score <8. Among patients with PCI ≤10, median OS after PDS was significantly higher than after early IDS or DDS. In women with PCI >10, there were no differences between PDS and early IDS, but DDS was associated with decreased OS. Conclusion: The benefit of complete PDS compared with NACT was maximal in patients with a low complexity score. In patients with low tumor burden, there was a survival benefit of PDS over early IDS or DDS. In women with high tumor load, DDS impaired the oncological outcome.
#Ovarian Neoplasms #Fallopian Tube Neoplasms #Peritoneal Neoplasms #Cytoreduction Surgical Procedures #Neoadjuvant Therapy #Tumor Burden

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참고문헌 (37)

참고문헌 신청
Chi DS / 2006 / What is the optimal goal of primary cytoreductive surgery for bulky stage IIIC epithelial ovarian carcinoma (EOC)? / Gynecol Oncol 103:559~564 google schola Ozols RF / 2003 / Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group study / J Clin Oncol 21:3194~3200 google schola Chiva L / 2016 / What should we expect after a complete cytoreduction at the time of interval or primary debulking surgery in advanced ovarian cancer? / Ann Surg Oncol 23:1666~1673 google schola Bristow RE / 2006 / Platinum-based neoadjuvant chemotherapy and interval surgical cytoreduction for advanced ovarian cancer: a meta-analysis / Gynecol Oncol 103:1070~1076 google schola Angeles MA / 2020 / A multivariate analysis of the prognostic impact of tumor burden, surgical timing and complexity after complete cytoreduction for advanced ovarian cancer / Gynecol Oncol 158:614~621 google schola

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