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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 477 - 488 (12page)
- DOI
- https://doi.org/10.1186/s40824-021-00236-4
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초록· 키워드
오류제보하기
Background: Carrageenan (CRN), a polygalactan consisting of 15 to 40% ester sulfate, is used in oral controlled release technology due to its viscosity and large molecular weight. Curcumin (Cur) is a highly potent antioxidant and anti-inflammatory agent against various diseases, such as tumors, liver disease, rheumatism, and Alzheimer’s disease. Although Cur shows excellent effects in the body, it has major problems, such as poor solubility and low bioavailability in water. Method: Nanocomposites containing Cur were developed by emulsion technique. Cur@CRN was characterized through the viscosity measurement, size analysis, stability test, and loading efficiency. Antioxidant effects was analyzed with DPPH reagent, and anti-inflammatory effects was analyzed by NFkB/IkBr signaling pathway with wester blot. Cellular interaction was confirmed by flow cytometry and confocal images. Especially, permeability test was demonstrated in MDCK and Caco-2 monolayer cells. Results: Cur@CRN enhanced stability, antioxidant, and anti-inflammatory effects in vitro, compared with other polymer nanocomposites. Sulfate groups (SO42?) in CRN are transported across cell membranes by anion exchangers of the SLC26 gene families. We confirmed Caco-2 cells expressed SLC26A2 receptors interacted with CRN, expect for Tween 80 and hydroxypropyl cellulose. In contrary, other cells did not interact with CRN due to non-expression of SLC26A2 receptors. Based on this, Cur@CRN showed 44-fold better permeability than free Cur in MDCK cell assay. Conclusion: Enhanced intestinal permeability of Cur can be applied in various health care facilities with significant antioxidant and anti-inflammatory effects compared with nonformulated Cur. Since the CRN composed of nanocomposites has a high molecular weight, high viscosity, and sulfate groups, it will be a platform that can increase the bioavailability of various insoluble drugs as well as Cur.
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참고문헌 (45)
참고문헌 신청
Yegappan R / 2018 / Carrageenan based hydrogels for drug delivery, tissue engineering and wound healing / Carbohydrate polymers 198:385~400
Necas J / 2013 / Carrageenan: a review / Veterinarni medicina 58(4):205
Ahmed K / 2012 / Nanoemulsion-and emulsion-based delivery systems for curcumin : encapsulation and release properties / Food Chem 132(2):799~807
Zaman M / 2016 / Gastrointestinal mucosa : the target site of Mucoadhesive microspheres / A Review Advances in Polymer Technology 35(3):269~276
Lalani R / 2021 / Applications of Polymers in Drug Delivery / Elsevier :105~129
Necas J / 2013 / Carrageenan: a review / Veterinarni medicina 58(4):205
Ahmed K / 2012 / Nanoemulsion-and emulsion-based delivery systems for curcumin : encapsulation and release properties / Food Chem 132(2):799~807
Zaman M / 2016 / Gastrointestinal mucosa : the target site of Mucoadhesive microspheres / A Review Advances in Polymer Technology 35(3):269~276
Lalani R / 2021 / Applications of Polymers in Drug Delivery / Elsevier :105~129
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