지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 535 - 552 (18page)
- DOI
- 10.3350/cmh.2021.0109
이용수
초록· 키워드
오류제보하기
Although patients with cirrhosis are known to be in a state of “rebalance” in that pro- and anticoagulant factors increase the risk for both bleeding and thrombosis, the prevalence of portal vein thrombosis (PVT) in patients with cirrhosis can be up to 26%. Therefore, physicians should consider anticoagulation for the prevention and management of PVT in patients with cirrhosis who are at high risk of PVT. Vitamin K antagonist or low molecular weight heparin is suggested as the standard treatment for PVT in cirrhosis. With the advent of new direct-acting oral anticoagulants (DOACs), there is a paradigm shift of switching to DOACs for the treatment of PVT in patients with cirrhosis. However, the safety and efficacy of DOACs in the treatment of PVT was not well-known in patients with cirrhosis. Therefore, this review focused on the current knowledge about the efficacy, safety concerns, and hepatic metabolism of DOACs in patients with cirrhosis and PVT.
목차
등록된 정보가 없습니다.
참고문헌 (91)
참고문헌 신청
Lisman T / 2017 / Pathogenesis, prevention, and management of bleeding and thrombosis in patients with liver diseases / Res Pract Thromb Haemost 1:150~161
Ghazaleh S / 2021 / Efficacy and safety of anticoagulation in non-malignant portal vein thrombosis in patients with liver cirrhosis : a systematic review and meta-analysis / Ann Gastroenterol 34:104~110
Tripodi A / 2011 / The coagulopathy of chronic liver disease / N Engl J Med 365:147~156
Kovalic AJ / 2020 / Systematic review with meta-analysis : abnormalities in the international normalised ratio do not correlate with periprocedural bleeding events among patients with cirrhosis / Aliment Pharmacol Ther 52:1298~1310
Drolz A / 2016 / Coagulation parameters and major bleeding in critically ill patients with cirrhosis / Hepatology 64:556~568
Ghazaleh S / 2021 / Efficacy and safety of anticoagulation in non-malignant portal vein thrombosis in patients with liver cirrhosis : a systematic review and meta-analysis / Ann Gastroenterol 34:104~110
Tripodi A / 2011 / The coagulopathy of chronic liver disease / N Engl J Med 365:147~156
Kovalic AJ / 2020 / Systematic review with meta-analysis : abnormalities in the international normalised ratio do not correlate with periprocedural bleeding events among patients with cirrhosis / Aliment Pharmacol Ther 52:1298~1310
Drolz A / 2016 / Coagulation parameters and major bleeding in critically ill patients with cirrhosis / Hepatology 64:556~568
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