지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 499 - 511 (13page)
- DOI
- 10.14366/usg.20122
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초록· 키워드
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Purpose: The aim of this study was to evaluate the association between the severity of hyperechoic pancreas (HP) on ultrasonography (US) and glycemic progression.Methods: In total, 1,386 participants who underwent abdominal US as part of health examinations between December 2008 and May 2014 were included in this retrospective study. We classified pancreatic echogenicity on a 4-point scale, and compared it using two distinct criteria: fatty pancreas (FP) 1 criterion (normal vs. ≥mild HP) and FP2 criterion (normal/mild HP vs. ≥moderate HP). According to the presence of nonalcoholic fatty liver disease (NAFLD), participants were subdivided into four groups: non-NAFLD and non-HP, isolated NAFLD, isolated HP, and HP with NAFLD. Glycemic progression was defined as progression from normoglycemia to prediabetes or diabetes or progression from prediabetes to diabetes.Results: During the follow-up (median, 5.9 years), 262 of the 1,386 participants developed glycemic progression. Using FP2, the probability of glycemic progression across the four subgroups showed cumulative aggravation for NAFLD and HP (all P<0.05). Isolated HP showed a higher probability of glycemic progression than isolated NAFLD according to FP2 (P<0.001). The highest probability of glycemic progression was observed in patients with both NAFLD and HP (P<0.001). The hazard ratio for glycemic progression increased with the severity of HP.Conclusion: Increasing severity of HP on US was found to be significantly correlated with glycemic progression. Moreover, isolated HP of moderate or greater severity predicted glycemic progression independent of NAFLD.
목차
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참고문헌 (40)
참고문헌 신청
Anstee QM / 2013 / Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis / Nat Rev Gastroenterol Hepatol 10:330~344
Chang Y / 2013 / Cohort study of non-alcoholic fatty liver disease, NAFLD fibrosis score, and the risk of incident diabetes in a Korean population / Am J Gastroenterol 108:1861~1868
Hamaguchi M / 2007 / Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease / World J Gastroenterol 13:1579~1584
Kotronen A / 2008 / Fatty liver: a novel component of the metabolic syndrome / Arterioscler Thromb Vasc Biol 28:27~38
Catanzaro R / 2016 / Exploring the metabolic syndrome: nonalcoholic fatty pancreas disease / World J Gastroenterol 22:7660~7675
Chang Y / 2013 / Cohort study of non-alcoholic fatty liver disease, NAFLD fibrosis score, and the risk of incident diabetes in a Korean population / Am J Gastroenterol 108:1861~1868
Hamaguchi M / 2007 / Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease / World J Gastroenterol 13:1579~1584
Kotronen A / 2008 / Fatty liver: a novel component of the metabolic syndrome / Arterioscler Thromb Vasc Biol 28:27~38
Catanzaro R / 2016 / Exploring the metabolic syndrome: nonalcoholic fatty pancreas disease / World J Gastroenterol 22:7660~7675
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