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학술저널
저자정보
Cho Yongin (Department of Endocrinology and Metabolism Inha University Hospital Inha University School of Medicine Incheon Korea.) Cho Yongin (Department of Endocrinology and Metabolism Inha University Hospital Inha University School of Medicine Incheon Korea.) 박혜선 (연세대학교) 허병욱 (허내과) 이용호 (연세대학교) 서승하 (인하대학교) 서다혜 (인하대학교) 안성희 (인하대학교) 홍성빈 (인하대학교) Kim So Hun (Department of Endocrinology and Metabolism Inha University Hospital Inha University School of Medicine Incheon Korea.) Kim So Hun (Department of Endocrinology and Metabolism Inha University Hospital Inha University School of Medicine Incheon Korea.)
저널정보
대한당뇨병학회 Diabetes and Metabolism Journal Diabetes and Metabolism Journal Vol.47 No.2
발행연도
2023.3
수록면
232 - 241 (10page)
DOI
10.4093/dmj.2021.0355

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Background: We aimed to evaluate whether non-alcoholic fatty liver disease (NAFLD) with or without sarcopenia is associated with progression of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM).Methods: We investigated 852 T2DM patients who underwent abdominal ultrasonography, bioelectrical impedance analysis, and carotid artery ultrasonography at baseline and repeated carotid ultrasonography after 6 to 8 years. NAFLD was confirmed by abdominal ultrasonography, and sarcopenia was defined as a sex-specific skeletal muscle mass index (SMI) value <2 standard deviations below the mean for healthy young adults. SMI was calculated by dividing the sum of appendicular skeletal mass by body weight. We investigated the association between NAFLD with or without sarcopenia and the progression of carotid atherosclerosis.Results: Of the 852 patients, 333 (39.1%) were classified as NAFLD without sarcopenia, 66 (7.7%) were classified as sarcopenia without NAFLD, and 123 (14.4%) had NAFLD with sarcopenia at baseline. After 6 to 8 years, patients with both NAFLD and sarcopenia had a higher risk of atherosclerosis progression (adjusted odds ratio, 2.20; P<0.009) than controls without NAFLD and sarcopenia. When a subgroup analysis was performed on only patients with NAFLD, female sex, absence of central obesity, and non-obesity were significant factors related to increased risk of plaque progression risk in sarcopenic patients.Conclusion: NAFLD with sarcopenia was significantly associated with the progression of carotid atherosclerosis in T2DM patients.

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