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논문 기본 정보

자료유형
학술저널
저자정보
유숙동 (Pusan National University) Cho Min Hyun (Department of Pediatrics Kyungpook National University School of Medicine Daegu Korea.) Baek Hee Sun (Department of Pediatrics Kyungpook National University School of Medicine Daegu Korea.) Song Ji Yeon (Department of Pediatrics Pusan National University Children's Hospital Yangsan Korea.) Lee Hye Sun (National Police Hospital) Yang Eun Mi (Chonnam National University Medical School & Children’s Hospital Gwangju Korea) 유기환 (고려대학교) Kim Su Jin (Inha University College of Medicine) Shin Jae Il (Department of Pediatrics Yonsei University College of Medicine Seoul Korea.) Lee Keum Hwa (Department of Pediatrics Yonsei University College of Medicine Seoul Korea.) 하태선 (충북대학교) Jang Kyung Mi (Yeungnam University Hospital) Lee Jung Won (Department of Internal Medicine Samsung Changwon Hospital Sungkyunkwan University School of Medicin) 김기혁 (일산대학교) Cho Heeyeon (Department of Pediatrics Samsung Medical Center School of Medicine Sungkyunkwan University Seoul Ko) 이미정 (단국대학교) Suh Jin-Soon (College of Medicine The Catholic University of Korea) Han Kyoung Hee (Department of Pediatrics College of Medicine Jeju National University Jeju Korea.) Hyun Hyesun (Department of Pediatrics College of Medicine St. Vincent’s Hospital The Catholic University of Kore) 하일수 (서울대학교) 정해일 (서울대학교) 강희경 (서울대학교) 남궁미경 (연세대학교) Cho Hye-Kyung (Gachon University) 오재혁 (아주대학교) 이상택 (삼성창원병원) Kim Kyo Sun (Department of Pediatrics Konkuk University Medical Center Seoul Korea.) Lee Joo Hoon (Department of Pediatrics Asan Medical Center Childrens' Hospital University of Ulsan College of Med) Park Young Seo (Department of Pediatrics Asan Medical Center Childrens' Hospital University of Ulsan College of Med) Kim Seong Heon (Pusan National University)
저널정보
대한신장학회 Kidney Research and Clinical Practice Kidney Research and Clinical Practice Vol.40 No.4
발행연도
2021.12
수록면
673 - 686 (14page)
DOI
10.23876/j.krcp.21.051

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Background: The clinical features of pediatric rhabdomyolysis differ from those of the adults with rhabdomyolysis; however, multi- center studies are lacking. This study aimed to investigate the characteristics of pediatric rhabdomyolysis and reveal the risk factors for acute kidney injury (AKI) in such cases. Methods: This retrospective study analyzed the medical records of children and adolescents diagnosed with rhabdomyolysis at 23 hospitals in South Korea between January 2007 and December 2016. Results: Among 880 patients, those aged 3 to 5 years old composed the largest subgroup (19.4%), and all age subgroups were pre- dominantly male. The incidence of AKI was 11.3%. Neurological disorders (53.6%) and infection (39.0%) were the most common un- derlying disorder and cause of rhabdomyolysis, respectively. The median age at diagnosis in the AKI subgroup was older than that in the non-AKI subgroup (12.2 years vs. 8.0 years). There were no significant differences in body mass index, myalgia, dark-colored urine, or the number of causal factors between the two AKI-status subgroups. The multivariate logistic regression model indicated that the following factors were independently associated with AKI: multiorgan failure, presence of an underlying disorder, strong posi- tive urine occult blood, increased aspartate aminotransferase and uric acid levels, and reduced calcium levels. Conclusion: Our study revealed characteristic clinical and laboratory features of rhabdomyolysis in a Korean pediatric population and highlighted the risk factors for AKI in these cases. Our findings will contribute to a greater understanding of pediatric rhabdomyolysis and may enable early intervention against rhabdomyolysis-induced AKI.
#Creatine kinase #Etiology #Muscles #Renal insufficiency

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참고문헌 (39)

참고문헌 신청
Panizo N / 2015 / Molecular mechanisms and novel therapeutic approaches to rhabdomyolysis-induced acute kidney injury / Kidney Blood Press Res 40:520~532 google schola Torres PA / 2015 / Rhabdomyolysis : pathogenesis, diagnosis, and treatment / Ochsner J 15:58~69 google schola Bosch X / 2009 / Rhabdomyolysis and acute kidney injury / N Engl J Med 361:62~72 google schola Chavez LO / 2016 / Beyond muscle destruction : a systematic review of rhabdomyolysis for clinical practice / Crit Care 20:135 google schola Szugye HS / 2020 / Pediatric Rhabdomyolysis / Pediatr Rev 41:265~275 google schola

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