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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 577 - 583 (7page)
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초록· 키워드
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Purpose: We aimed to investigate whether the use of cardiovascular drugs in coronavirus disease 2019 (COVID-19) patients withhypertension as a comorbidity has a significant effect on the incidence and associated mortality rate of COVID-19. Materials and Methods: Data covering the period between January 1, 2020 and June 4, 2020 were extracted from The NationalHealth Insurance Service-COVID-19 (NHIS-COVID-19) database in South Korea and analyzed as a population-based cohort study. Results: A total of 101657 hypertensive adults aged 20 years or older were included for final analysis. Among them, 1889 patients(1.9%) were diagnosed with COVID-19 between January 1, 2020 and June 4, 2020, and hospital mortality occurred in 193 patients(10.2%). In a multivariable model, the use of beta-blockers was associated with an 18% lower incidence of COVID-19 [odds ratio(OR): 0.82, 95% confidence interval (CI): 0.69?0.98; p=0.029]. Among 1889 hypertensive patients diagnosed with COVID-19, theuse of a calcium channel blocker (CCB) was associated with a 42% lower hospital mortality rate (OR: 0.58, 95% CI: 0.38?0.89;p=0.012). The use of other cardiovascular drugs was not associated with the incidence of COVID-19 or hospital mortality rateamong COVID-19 patients. Similar results were observed in all 328374 adults in the NHIS-COVID-19 database, irrespective of thepresence of hypertension. Conclusion: In South Korea, beta-blockers exhibited potential benefits in lowering the incidence of COVID-19 among hypertensivepatients. Furthermore, CCBs may lower the hospital mortality rate among hypertensive COVID-19 patients. These findingswere also applied to the general adult population, regardless of hypertension
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참고문헌 (33)
참고문헌 신청
Bedford J / 2020 / COVID-19 : towards controlling of a pandemic / Lancet 395:1015~1018
Johns Hopkins University & Medicine / Coronavirus Resource Center. Global map of cases and deaths by country/region/sovereignty
Dagan N / 2021 / BNT162b2 mRNA covid-19 vaccine in a nationwide mass vaccination setting / N Engl J Med 384:1412~1423
Knoll MD / 2021 / Oxford-AstraZeneca COVID-19 vaccine efficacy / Lancet 397:72~74
Fontanet A / 2020 / COVID-19 herd immunity: where are we? / Nat Rev Immunol 20:583~584
Johns Hopkins University & Medicine / Coronavirus Resource Center. Global map of cases and deaths by country/region/sovereignty
Dagan N / 2021 / BNT162b2 mRNA covid-19 vaccine in a nationwide mass vaccination setting / N Engl J Med 384:1412~1423
Knoll MD / 2021 / Oxford-AstraZeneca COVID-19 vaccine efficacy / Lancet 397:72~74
Fontanet A / 2020 / COVID-19 herd immunity: where are we? / Nat Rev Immunol 20:583~584
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