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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 706 - 716 (11page)
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Purpose This study evaluated the re-challenge of S-1 or cisplatin in combination with docetaxel in metastatic gastric cancer (MGC) that had progressed on a cisplatin plus either S-1 or capecitabine regimen.
Materials and Methods Patients with progressive disease after first-line cisplatin plus S-1 or capecitabine were randomized to receive 3-week cycles of docetaxel 75 mg/m2 intravenously (IV) on D1 (D), docetaxel 60 mg/m2 IV plus cisplatin 60 mg/m" IV on D1 (DC), or docetaxel 60 mg/m2 IV D1 plus oral S-1 30 mg/m2 twice a day on D1-14 (DS).
Results Seventy-two patients were randomized to the D (n=23), DC (n=24), or DS (n=25) group.
The confirmed response rate was 4.3% (95% confidence interval [CI], 0% to 12.6%), 4.3% (95% CI, 0% to 12.6%), and 8.7% (95% CI, 0% to 20.2%) for the D, DC, and DS groups, respectively. Compared to the D arm, the DS arm had a better progression-free survival (2.7 months vs. 1.3 months, p=0.034) without any deterioration in safety or quality of life, whereas the DC arm had a similar progression-free survival (1.8 months vs. 1.3 months, p=0.804) and poorer overall survival (5.6 months vs. 10.0 months, p=0.035).
Conclusion A re-challenge with S-1, but not cisplatin, in combination with docetaxel has potential anticancer benefits over docetaxel alone in MGC with progression after prior cisplatin plus S-1 or capecitabine.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
정규원 / 2015 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2012 / Cancer Research and Treatment 47(2):127~141
Glimelius B / 1997 / Randomized comparison between chemotherapy plus best supportive care with best supportive care in advanced gastric cancer / Ann Oncol 8:163~168
Kang YK / 2009 / Capecitabine/cisplatin versus 5-fluorouracil/cisplatin as firstline therapy in patients with advanced gastric cancer : a randomised phase III noninferiority trial / Ann Oncol 20:666~673
Cunningham D / 2008 / Capecitabine and oxaliplatin for advanced esophagogastric cancer / N Engl J Med 358:36~46
Ajani JA / 2010 / Multicenter phase III comparison of cisplatin/S-1 with cisplatin/infusional fluorouracil in advanced gastric or gastroesophageal adenocarcinoma study : the FLAGS trial / J Clin Oncol 28:1547~1553
Glimelius B / 1997 / Randomized comparison between chemotherapy plus best supportive care with best supportive care in advanced gastric cancer / Ann Oncol 8:163~168
Kang YK / 2009 / Capecitabine/cisplatin versus 5-fluorouracil/cisplatin as firstline therapy in patients with advanced gastric cancer : a randomised phase III noninferiority trial / Ann Oncol 20:666~673
Cunningham D / 2008 / Capecitabine and oxaliplatin for advanced esophagogastric cancer / N Engl J Med 358:36~46
Ajani JA / 2010 / Multicenter phase III comparison of cisplatin/S-1 with cisplatin/infusional fluorouracil in advanced gastric or gastroesophageal adenocarcinoma study : the FLAGS trial / J Clin Oncol 28:1547~1553
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