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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제25권 제6호
- 발행연도
- 2021.10
- 수록면
- 555 - 564 (10page)
- DOI
- 10.4196/kjpp.2021.25.6.555
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초록· 키워드
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We investigated the effects of naringenin and morin on IL-5 and ROS production in PMA+ionomycin-treated EL-4 cells with the corroboration of their antioxidant and anti-inflammatory properties using an asthma-induced mouse model. The EL-4 cell line was used to study the outcomes of naringenin or morin, followed by cell viability studies. Western blot analysis and ELISA test were used to determine Th2 mediated cytokines. In vivo studies were carried out on BALB/c mice to induce allergic asthma using ovalbumin administered intraperitoneally. Intracellular ROS was determined using 2’,7’-dichlorodihydrofluorescein diacetate, followed by serum enzymatic (AST and ALT) estimations and inflammatory cell count in the bronchoalveolar lavage fluid (BALF) and lung tissues. Histopathological studies were conducted to examine lung tissue-stained architecture. Our findings suggested that naringenin and morin significantly suppressed IL-5 and ROS production via various pathways.
Interestingly, by reducing NFAT activity, naringenin and morin stimulated HO-1 expression, thereby suppressing IL-5 secretion due to regulating the transcription factor Nrf2 via P13/Akt or ERK/JNK signalling pathways in EL-4 cells, demonstrating the involvement of HO-1 expression in inhibiting asthmatic inflammation. The increased inflammatory cells in the BALF were substantially decreased by both naringenin and morin, followed by inhibition in the elevated Th-2 cytokines levels. The TNF-α protein levels in an allergic asthma mouse model were significantly reduced by suppressing Akt phosphorylation and eosinophil formation. Recent findings confirmed that naringenin and morin possess the potential to control asthma-related immune responses through antioxidant and anti-inflammatory properties, indicating potential therapeutic agents or functional foods
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참고문헌 (50)
참고문헌 신청
Chung MJ / 2012 / Anti-inflammatory effects of lowmolecular weight chitosan oligosaccharides in IgE-antigen complexstimulated RBL-2H3 cells and asthma model mice / Int Immunopharmacol 12:453~459
Berend N / 2008 / Mechanisms of airway hyperresponsiveness in asthma / Respirology 13:624~631
Cockcroft DW / 2006 / Mechanisms of airway hyperresponsiveness / J Allergy Clin Immunol 118:quiz 560~quiz 561
Gong JH / 2012 / Kaempferol suppresses eosionphil infiltration and airway inflammation in airway epithelial cells and in mice with allergic asthma / J Nutr 142:47~56
Goh FY / 2012 / Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB / Eur J Pharmacol 679:109~116
Berend N / 2008 / Mechanisms of airway hyperresponsiveness in asthma / Respirology 13:624~631
Cockcroft DW / 2006 / Mechanisms of airway hyperresponsiveness / J Allergy Clin Immunol 118:quiz 560~quiz 561
Gong JH / 2012 / Kaempferol suppresses eosionphil infiltration and airway inflammation in airway epithelial cells and in mice with allergic asthma / J Nutr 142:47~56
Goh FY / 2012 / Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB / Eur J Pharmacol 679:109~116
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