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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제5호
- 발행연도
- 2018.9
- 수록면
- 493 - 501 (9page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.5.493
이용수
초록· 키워드
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The present study was carried out with the hypothesis that combination of canagliflozin and omega-3 fatty acid may have potential effect on insulin level, insulin resistance, cardiac biomarkers, inflammatory cytokines and histological studies in type 2 diabetes mellitus (DM). Type 2 DM was induced by injecting nicotinamide (120 mg/kg, i.p.) 15 min before STZ (60 mg/kg) injection. Canagliflozin (5 and 10 mg/kg) and omega-3 fatty acid (300 mg/kg) were given for 28 days after confirmation of diabetes. Biochemical estimations revealed elevated levels of glucose, insulin, HOMA-R and inflammatory cytokines in diabetic group. Daily dosing of alone canagliflozin and omega-3 fatty acid slightly reduced elevated levels of glucose, insulin, HOMA-R and inflammatory cytokines (IL-1β, IL-2, and TNFα), whereas canagliflozin and omega-3 fatty acid combination has reduced these biochemical parameters significantly when compared with diabetic group. Similarly in diabetic group the levels of cardiac biomarkers such as lipid profile, LDH, CKMB and troponin were significantly increased. Elevated levels of cardiac biomarkers were significantly reduced after daily dosing of alone canagliflozin and omega-3 fatty acid. Canagliflozin and omega-3 fatty acid combination has offered better improvement in cardiac biomarkers compared to alone canagliflozin and omega-3 fatty acid. Histopathological analysis also supported the above hypothesis that combination therapy (canagliflozin and omega-3 fatty acid) offered better protection against degenerative changes in β-cells of pancreas as compared to alone treatment with these drugs. Thus the present study revealed that canagliflozin and omega-3 fatty acid can be used as potential combination therapy in type 2 DM along with cardiac complication.
목차
등록된 정보가 없습니다.
참고문헌 (37)
참고문헌 신청
American Diabetes Association / 2014 / Diagnosis and classification of diabetes mellitus / Diabetes Care 37(Suppl 1):S81~S90
2011 / IDF Diabetes Atlas 5th edition [Internet]
Alqurashi KA / 2011 / Prevalence of diabetes mellitus in a Saudi community / Ann Saudi Med 31:19~23
Zimmet P / 2003 / Genotype, obesity and cardiovascular disease-has technical and social advancement outstripped evolution? / J Intern Med 254:114~125
Barrett-Connor EL / 1991 / Why is diabetes mellitus a stronger risk factor for fatal ischemic heart disease in women than in men? The Rancho Bernardo Study / JAMA 265:627~631
2011 / IDF Diabetes Atlas 5th edition [Internet]
Alqurashi KA / 2011 / Prevalence of diabetes mellitus in a Saudi community / Ann Saudi Med 31:19~23
Zimmet P / 2003 / Genotype, obesity and cardiovascular disease-has technical and social advancement outstripped evolution? / J Intern Med 254:114~125
Barrett-Connor EL / 1991 / Why is diabetes mellitus a stronger risk factor for fatal ischemic heart disease in women than in men? The Rancho Bernardo Study / JAMA 265:627~631
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