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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제3호
- 발행연도
- 2018.5
- 수록면
- 257 - 267 (11page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.3.257
이용수
초록· 키워드
오류제보하기
The present study aimed to evaluate the cinnamic acid effect on memory impairment, oxidative stress, and cholinergic dysfunction in streptozotocin (STZ)-induced diabetic model in mice. In this experimental study, 48 male Naval Medical Research Institute (NMRI) mice (30-35 g) were chosen and were randomly divided into six groups: control, cinnamic acid (20 mg/kg day, i.p.), diabetic, and cinnamic acidtreated diabetic (10, 20 and 40 mg/kg day, i.p.). Memory was impaired by administering an intraperitoneal STZ injection of 50 mg/kg. Cinnamic acid was injected for 40 days starting from the 21st day after confirming STZ-induced dementia to observe its therapeutic effect. Memory function was assessed using cross-arm maze, morris water maze and passive avoidance test. After the administration, biochemical parameters of oxidative stress and cholinergic function were estimated in the brain. Present data indicated that inducing STZ caused significant memory impairment, whereas administration of cinnamic acid caused significant and dose-dependent memory improvement. Assessment of brain homogenates indicated cholinergic dysfunction, increase in lipid peroxidation and reactive oxygen species (ROS) levels, and decrease in glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) activities in the diabetic group compared to the control animals, whereas cinnamic acid administration ameliorated these indices in the diabetic mice. The present study demonstrated that cinnamic acid improves memory by reducing the oxidative stress and cholinergic dysfunction in the brain of diabetic mice.
목차
등록된 정보가 없습니다.
참고문헌 (78)
참고문헌 신청
Rohit Kumar / 2010 / Effects of Erythropoietin on Memory Deficits and Brain Oxidative Stress in the Mouse Models of Dementia / The Korean Journal of Physiology & Pharmacology 14(5):345~352
Yki-Jarvinen H / 2004 / Thiazolidinediones / N Engl J Med 351:1106~1118
Liu X / 2016 / Naringin ameliorates cognitive deficits in streptozotocin-induced diabetic rats / Iran J Basic Med Sci 19:417~422
Moghadamnia AA / 2015 / Vitamin D improves learning and memory impairment in streptozotocin-induced diabetic mice / Arch Iran Med 18:362~366
Hasanein P / 2010 / Effects of combined treatment with vitamins C and E on passive avoidance learning and memory in diabetic rats / Neurobiol Learn Mem 93:472~478
Yki-Jarvinen H / 2004 / Thiazolidinediones / N Engl J Med 351:1106~1118
Liu X / 2016 / Naringin ameliorates cognitive deficits in streptozotocin-induced diabetic rats / Iran J Basic Med Sci 19:417~422
Moghadamnia AA / 2015 / Vitamin D improves learning and memory impairment in streptozotocin-induced diabetic mice / Arch Iran Med 18:362~366
Hasanein P / 2010 / Effects of combined treatment with vitamins C and E on passive avoidance learning and memory in diabetic rats / Neurobiol Learn Mem 93:472~478
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