지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 570 - 576 (7page)
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초록· 키워드
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Background: Inflammatory factors and β-cell dysfunction due to high-fat diets aggravate chronic diseases and their complications. However, omega-3 dietary fats have anti-inflammatory effects, and the involvement of autophagy in the etiology of diabetes has been reported. Therefore, we examined the protective effects of autophagy on diabetes using fat-1 transgenic mice with omega-3 self-synthesis capability. Methods: Streptozotocin (STZ) administration induced β-cell dysfunction in mice; blood glucose levels and water consumption were subsequently measured. Using hematoxylin and eosin (H&E) and Masson’s trichrome staining, we quantitatively assessed STZ-induced changes in the number, mass, and fibrosis of pancreatic islets in fat-1 and control mice. We identified the microtubule-associated protein 1A/1B light chain 3-immunoreactive puncta in β-cells and quantified p62 levels in the pancreas of fat-1 and control mice. Results: STZ-induced diabetic phenotypes, including hyperglycemia and polydipsia, were attenuated in fat-1 mice. Histological determination using H&E and Masson’s trichrome staining revealed the protective effects of the fat-1 expression on cell death and the scarring of pancreatic islets after STZ injection. In the β-cells of control mice, autophagy was abruptly activated after STZ treatment. Basal autophagy levels were elevated in fat-1 mice β-cells, and this persisted after STZ treatment. Together with autophagosome detection, these results revealed that n-3 polyunsaturated fatty acid (PUFA) enrichment might partly prevent the STZ-related pancreatic islet damage by upregulating the basal activity of autophagy and improving autophagic flux disturbance. Conclusion: Fat-1 transgenic mice with a n-3 PUFA self-synthesis capability exert protective effects against STZ-induced β-cell death by activating autophagy in β-cells.
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등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Kahn CR / 2005 / Chapter 24, Insulin resistance and its role in the pathogenesis of type 2 diabetes / Lippincott Williams & Wilkins :425~448
Franz MJ / 2003 / Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications / Diabetes Care 26(Suppl 1):S51~S61
Kesavulu MM / 2002 / Effect of omega-3 fatty acids on lipid peroxidation and antioxidant enzyme status in type 2 diabetic patients / Diabetes Metab 28:20~26
Calder PC / 2006 / n-3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases / Am J Clin Nutr 83(6 Suppl):1505S~1519S
Marchetti P / 2009 / Autophagy and the pancreatic beta-cell in human type 2 diabetes / Autophagy 5:1055~1056
Franz MJ / 2003 / Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications / Diabetes Care 26(Suppl 1):S51~S61
Kesavulu MM / 2002 / Effect of omega-3 fatty acids on lipid peroxidation and antioxidant enzyme status in type 2 diabetic patients / Diabetes Metab 28:20~26
Calder PC / 2006 / n-3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases / Am J Clin Nutr 83(6 Suppl):1505S~1519S
Marchetti P / 2009 / Autophagy and the pancreatic beta-cell in human type 2 diabetes / Autophagy 5:1055~1056
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