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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제5호
- 발행연도
- 2017.9
- 수록면
- 555 - 563 (9page)
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초록· 키워드
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Electrical stimulation through retinal prosthesis elicits both short and long-latency retinal ganglion cell (RGC) spikes. Because the short-latency RGC spike is usually obscured by electrical stimulus artifact, it is very important to isolate spike from stimulus artifact. Previously, we showed that topographic prominence (TP) discriminator based algorithm is valid and useful for artifact subtraction. In this study, we compared the performance of forward backward (FB) filter only vs. TP-adopted FB filter for artifact subtraction. From the extracted retinae of rd1 mice, we recorded RGC spikes with 8×8 multielectrode array (MEA). The recorded signals were classified into four groups by distances between the stimulation and recording electrodes on MEA (200-400, 400-600, 600-800, 800-1000 μm). Fifty cathodic phase-1st biphasic current pulses (duration 500 μs, intensity 5, 10, 20, 30, 40, 50, 60 μA) were applied at every 1 sec. We compared false positive error and false negative error in FB filter and TP-adopted FB filter. By implementing TP-adopted FB filter, short-latency spike can be detected better regarding sensitivity and specificity for detecting spikes regardless of the strength of stimulus and the distance between stimulus and recording electrodes.
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참고문헌 (33)
참고문헌 신청
Shintani K / 2009 / Review and update : current treatment trends for patients with retinitis pigmentosa / Optometry 80:384~401
Mehta S / 2015 / Age-related macular degeneration / Prim Care 42:377~391
Kim SY / 2002 / Morphometric analysis of the macula in eyes with disciform age-related macular degeneration / Retina 22:471~477
Mazzoni F / 2008 / Retinal ganglion cells survive and maintain normal dendritic morphology in a mouse model of inherited photoreceptor degeneration / J Neurosci 28:14282~14292
Santos A / 1997 / Preservation of the inner retina in retinitis pigmentosa. A morphometric analysis / Arch Ophthalmol 115:511~515
Mehta S / 2015 / Age-related macular degeneration / Prim Care 42:377~391
Kim SY / 2002 / Morphometric analysis of the macula in eyes with disciform age-related macular degeneration / Retina 22:471~477
Mazzoni F / 2008 / Retinal ganglion cells survive and maintain normal dendritic morphology in a mouse model of inherited photoreceptor degeneration / J Neurosci 28:14282~14292
Santos A / 1997 / Preservation of the inner retina in retinitis pigmentosa. A morphometric analysis / Arch Ophthalmol 115:511~515
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