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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 900 - 907 (8page)
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초록· 키워드
오류제보하기
Retinal implants have been developed as a promising way to restore partial vision for the blind. The observation and analysis of neural activities can offer valuable insights for successful prosthetic electrical stimulation. Retinal ganglion cell (RGC) activities have been investigated to provide knowledge on the requirements for electrical stimulation, such as threshold current and the effect of stimulation waveforms. To develop a detailed ‘stimulation strategy’ for faithful delivery of spatiotemporal visual information to the brain, it is essential to examine both the temporal and spatial characteristics of RGC responses, whereas previous studies were mainly focused on one or the other. In this study, we investigate whether the spatiotemporal visual information can be decoded from the RGC network activity evoked by patterned electrical stimulation. Along with a thorough characterization of spatial spreading of stimulation current and temporal information encoding, we demonstrated that multipixel spatiotemporal visual information can be accurately decoded from the population activities of RGCs stimulated by amplitude-modulated pulse trains. We also found that the details of stimulation, such as pulse amplitude range and pulse rate, were crucial for accurate decoding. Overall, the results suggest that useful visual function may be restored by amplitude modulation-based retinal stimulation.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Ryu SB / 2010 / Temporal response properties of retinal ganglion cells in rd1 mice evoked by amplitude-modulated electrical pulse trains / Invest Ophthalmol Vis Sci 51:6762~6769
Merabet LB / 2005 / What blindness can tell us about seeing again : merging neuroplasticity and neuroprostheses / Nat Rev Neurosci 6:71~77
Zrenner E / 2011 / Subretinal electronic chips allow blind patients to read letters and combine them to words / Proc Biol Sci 278:1489~1497
Barry MP / 2012 / Use of the Argus II retinal prosthesis to improve visual guidance of fine hand movements / Invest Ophthalmol Vis Sci 53:5095~5101
Pérez Fornos A / 2012 / Temporal properties of visual perception on electrical stimulation of the retina / Invest Ophthalmol Vis Sci 53:2720~2731
Merabet LB / 2005 / What blindness can tell us about seeing again : merging neuroplasticity and neuroprostheses / Nat Rev Neurosci 6:71~77
Zrenner E / 2011 / Subretinal electronic chips allow blind patients to read letters and combine them to words / Proc Biol Sci 278:1489~1497
Barry MP / 2012 / Use of the Argus II retinal prosthesis to improve visual guidance of fine hand movements / Invest Ophthalmol Vis Sci 53:5095~5101
Pérez Fornos A / 2012 / Temporal properties of visual perception on electrical stimulation of the retina / Invest Ophthalmol Vis Sci 53:2720~2731
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