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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한마취통증의학회(구 대한마취과학회) Korean Journal of Anesthesiology Korean Journal of Anesthesiology Vol.74 No.6
- 발행연도
- 2021.12
- 수록면
- 531 - 540 (10page)
- DOI
- 10.4097/kja.21155
이용수
초록· 키워드
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Background: Cerebral blood flow (CBF) has direct effects on neuronal function and neurocognitive disorders. Oxidative stress from abdominal aortic surgery is important in the pathophysiology of CBF impairment. We investigated the effect of edaravone on the pial arteriolar diameter changes induced by abdominal aortic surgery and the involvement of the endothelium in the changes.Methods: The closed cranial window technique was used in rabbits to measure changes in pial arteriolar diameter after the unclamping of abdominal aortic cross-clamping with an intravenous free radical scavenger, edaravone (control group [n = 6], edaravone 10 μg/kg/min [n = 6], 100 μg/kg/min [n = 6]). Pial vasodilatory responses to topical application of acetylcholine (ACh) into the cranial window were investigated before abdominal aortic cross-clamping and after unclamping with intravenous administration of edaravone (control group [n = 6], edaravone 100 μg/kg/min [n = 6]).Results: Aortic unclamping-induced vasoconstriction was significantly attenuated by continuous infusion of edaravone at 100 μg/kg/min. Topical ACh after unclamping did not produce any changes in pial arteriolar responses in comparison to before aortic cross-clamping in the control or edaravone groups. The changes in the response to topical ACh after unclamping in the saline and edaravone groups did not differ significantly.Conclusions: Free radicals during abdominal aortic surgery might have contracted cerebral blood vessels independently of endothelial function in rabbits. Suppression of free radicals attenuated the sustained pial arteriolar vasoconstriction after aortic unclamping. Thus, the free radical scavenger might have some brain protective effect that maintains CBF independently of endothelial function.
목차
등록된 정보가 없습니다.
참고문헌 (48)
참고문헌 신청
Gelman S / 1995 / The pathophysiology of aortic cross-clamping and unclamping / Anesthesiology 82:1026~1060
Ogoh S / 2017 / Relationship between cognitive function and regulation of cerebral blood flow / J Physiol Sci 67:345~351
Marcantonio ER / 1994 / A clinical prediction rule for delirium after elective noncardiac surgery / JAMA 271:134~139
Visser L / 2015 / Predicting postoperative delirium after vascular surgical procedures / J Vasc Surg 62:183~189
Raats JW / 2016 / Risk factors of post-operative delirium after elective vascular surgery in the elderly : a systematic review / Int J Surg 35:1~6
Ogoh S / 2017 / Relationship between cognitive function and regulation of cerebral blood flow / J Physiol Sci 67:345~351
Marcantonio ER / 1994 / A clinical prediction rule for delirium after elective noncardiac surgery / JAMA 271:134~139
Visser L / 2015 / Predicting postoperative delirium after vascular surgical procedures / J Vasc Surg 62:183~189
Raats JW / 2016 / Risk factors of post-operative delirium after elective vascular surgery in the elderly : a systematic review / Int J Surg 35:1~6
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