지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.4
- 수록면
- 72 - 81 (10page)
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Abdominal aortic aneurysm (AAA) is a chronic dilation of the aorta with a tendency to enlarge and eventually rupture, which constitutes a major cause of cardiovascular mortality. Although T-cell infiltrates have been observed in AAA, the cellular, phenotypic, and functional characteristics of these tissue-infiltrating T cells are not fully understood. Here, we investigated the proportional changes of T-cell subsets—including CD4<SUP>+</SUP> T cells, CD8<SUP>+</SUP> T cells, and γδ T cells—and their effector functions in AAAs. We found that Vδ2<SUP>+</SUP> T cells were presented at a higher frequency in aortic aneurysmal tissue compared to normal aortic tissue and PBMCs from patients with AAA. In contrast, no differences were observed in the frequencies of CD4<SUP>+</SUP>, CD8<SUP>+</SUP>, and Vδ1<SUP>+</SUP> T cells. Moreover, we observed that the Vδ2<SUP>+</SUP> T cells from AAA tissue displayed immunophenotypes indicative of CCR5<SUP>+</SUP> non-exhausted effector memory cells, with a decreased proportion of CD16<SUP>+</SUP> cells. Finally, we found that these Vδ2<SUP>+</SUP> T cells were the main source of IL-17A in abdominal aortic aneurysmal tissue. In conclusion, our results suggest that increased Vδ2<SUP>+</SUP> T cells that robustly produce IL-17A in aortic aneurysmal tissue may contribute to AAA pathogenesis and progression.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2021-517-001751680