Investigation of a pre-clinical mandibular bone notch defect model  in miniature pigs: clinical computed tomography,  micro-computed tomography, and histological evaluation

Patricia L. Carlisle; Teja Guda; David T. Silliman; Wen Lien; Robert G. Hale; Pamela R. Brown Baer

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자료유형: 학술저널

저자정보: Patricia L. Carlisle Teja Guda David T. Silliman Wen Lien Robert G. Hale Pamela R. Brown Baer

저널정보: 대한구강악안면외과학회 대한구강악안면외과학회지 대한구강악안면외과학회지 제42권 제1호

발행연도: 2016.1

수록면: 20 - 30 (11page)

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Objectives: To validate a critical-size mandibular bone defect model in miniature pigs.Materials and Methods: Bilateral notch defects were produced in the mandible of dentally mature miniature pigs. The right mandibular defect remained untreated while the left defect received an autograft. Bone healing was evaluated by computed tomography (CT) at 4 and 16 weeks, and by micro-CT and non-decalcified histology at 16 weeks.Results: In both the untreated and autograft treated groups, mineralized tissue volume was reduced significantly at 4 weeks post-surgery, but was comparable to the pre-surgery levels after 16 weeks. After 16 weeks, CT analysis indicated that significantly greater bone was regenerated in the auto-graft treated defect than in the untreated defect (P=0.013). Regardless of the treatment, the cortical bone was superior to the defect remodeled over 16 weeks to compensate for the notch defect.Conclusion: The presence of considerable bone healing in both treated and untreated groups suggests that this model is inadequate as a critical-size defect. Despite healing and adaptation, the original bone geometry and quality of the pre-injured mandible was not obtained. On the other hand, this model is justified for evaluating accelerated healing and mitigating the bone remodeling response, which are both important considerations for dental implant restorations.

#Mandible #Autografts #Bone regeneration #Porcine #Critical-size defect

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