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논문 기본 정보

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학술저널
저자정보
Minjoo Kim (Jeonbuk National University Medical School and Hospital) 김은미 (전북대학교병원) Phil-Sun Oh (Jeonbuk National University Medical School and Hospital) Seok Tae Lim (Jeonbuk National University Medical School and Hospital) Myung-Hee Sohn (Jeonbuk National University Medical School and Hospital) Eun-Kee Song (Jeonbuk National University Medical School and Hospital) Keon Uk Park (Keimyung University Dongsan Hospital) Jin Young Kim (Keimyung University Dongsan Hospital) Kyoung Sook Won (Keimyung University Dongsan Hospital) Hwan-Jeong Jeong (Jeonbuk National University Medical School and Hospital)
저널정보
대한통증학회 The Korean Journal of Pain The Korean Journal of Pain 제34권 제4호
발행연도
2021.10
수록면
427 - 436 (10page)
DOI
10.3344/kjp.2021.34.4.427

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Background: Pharmacological and non-pharmacological therapies have been used to treat patients with chemotherapy-induced peripheral neuropathy (CIPN). However, the effect of therapies in cancer patients has yet to be investigated comprehensively. We hypothesized that cyclic thermal therapy would improve blood flow and microcirculation and improve the symptoms driven by CIPN. Methods: The criteria of assessment were blood volume in region of interest (ROI) in the images, and European Organization for Research and Treatment of Cancer? Quality of Life Questionnaire?Chemotherapy-Induced Peripheral Neuropathy 20 questionnaire scores. The blood volume was quantified by using red blood cell (RBC) scintigraphy. All patients were treated 10 times during 10 days. The thermal stimulations, between 15° and 41°, were repeatedly delivered to the patient’s hands. Results: The total score of the questionnaires, the score of questions related to the upper limbs, the score of questions closely related to the upper limbs, and the score excluding the upper limbs questions was decreased. The blood volume was decreased, and the variance of blood volume was decreased. During cooling stimulation, the blood volume was decreased, and its variance was decreased. During warming stimulation, the blood volume was decreased, and its variance was decreased. Conclusions: We suggest that cyclic thermal therapy is useful to alleviate CIPN symptoms by blood circulation improvement. RBC scintigraphy can provide the quantitative information on blood volume under certain conditions such as stress, as well as rest, in peripheral tissue.
#Antineoplastic Agents #Blood Volume #Drug-Related Side Effects and Adverse Reactions #Drug Therapy #Microcirculation #Neuralgia #Peripheral Nervous System Diseases #Polyneuropathies #Radionuclide Imaging #Scintigraphy #Small Fiber Neuropathy.

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참고문헌 (27)

참고문헌 신청
Windebank AJ / 2008 / Chemotherapy-induced neuropathy / J Peripher Nerv Syst 13:27~46 google schola Armstrong T / 2005 / Chemotherapyinduced peripheral neuropathy / Oncol Nurs Forum 32:305~311 google schola Kumar SP / 2013 / Chemotherapy-induced or chemotherapy-associated? Does physical therapy play a role in prevention and/or management of peripheral neurotoxicity and neuropathy? / Indian J Palliat Care 19:77~78 google schola Wolf S / 2008 / Chemotherapy-induced peripheral neuropathy : prevention and treatment strategies / Eur J Cancer 44:1507~1515 google schola 우인숙 / 2015 / 항암제에 의한 말초 신경병증의 최신 지견 / 대한내과학회지 88(1):35~37 dbpia

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