지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 792 - 798 (7page)
- DOI
- 10.3349/ymj.2021.62.9.792
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초록· 키워드
오류제보하기
Purpose: In this prospective study, we evaluated the association between the serum levels of antioxidants uric acid (UA), albumin,and total bilirubin and the risk of cancer in a Korean population.
Materials and Methods: A total of 15882 subjects were followed up for cancer development and cancer-related death. During thefollow-up period, 1619 cancer diagnoses and 617 cancer-related deaths were recorded. Cox proportional regression was performedto calculate the hazard ratio (HR) per standard deviation (SD) increment and 95% confidence interval (CI). The model was adjustedfor covariates such as the age, sex, smoking, alcohol consumption, physical activity, education level, body mass index, andfamily history. Sensitivity analyses using the study subjects with physiological serum levels of each indicator were also performed.
Results: UA levels were positively correlated with cancer risk (HR per SD increment 1.04; 95% CI, 1.01?1.09), and albumin levelswere inversely associated with the overall cancer risk (HR, 0.92; 95% CI, 0.88?0.96) and cancer-related death (HR, 0.86; 95% CI,0.80?0.93). Total bilirubin levels were negatively correlated with the risk of cancer-related death (HR, 0.91; 95% CI, 0.83?0.99). Bycancer type, UA was positively associated with prostate cancer, total bilirubin was positively associated with liver cancer, and albuminwas inversely associated with lung cancer.
Conclusion: The findings of this study support the role of antioxidants in carcinogenesis. Future large-cohort studies are needed toconfirm the predictive value of albumin, UA, and total bilirubin levels in each type of cancer.
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