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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한악안면성형재건외과학회 Maxillofacial Plastic Reconstructive Surgery Maxillofacial Plastic Reconstructive Surgery 제40권 제44호
- 발행연도
- 2018.12
- 수록면
- 1 - 17 (17page)
- DOI
- https://doi.org/10.1186/s40902-018-0183-z
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초록· 키워드
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Background: Coffee extract has been investigated by many authors, and many minor components of coffee are known, such as polyphenols, diterpenes (kahweol and cafestol), melanoidins, and trigonelline, to have anti-inflammatory, anti-oxidant, anti-angiogenic, anticancer, chemoprotective, and hepatoprotective effects.
Therefore, it is necessary to know its pharmacological effect on hepatocytes which show the most active cellular regeneration in body.
Methods: In order to determine whether coffee extract has a beneficial effect on the liver, 20 C57BL/6J mice were intraperitoneally injected once with dialyzed coffee extract (DCE)-2.5 (equivalent to 2.5 cups of coffee a day in man), DCE-5, or DCE-10, or normal saline (control), and then followed by histological observation and IP-HPLC (immunoprecipitation high performance liquid chromatography) over 24 h.
Results: Mice treated with DCE-2.5 or DCE-5 showed markedly hypertrophic hepatocytes with eosinophilic cytoplasms, while those treated with DCE-10 showed slightly hypertrophic hepatocytes, which were well aligned in hepatic cords with increased sinusoidal spaces. DCE induced the upregulations of cellular proliferation, growth factor/RAS signaling, cellular protection, p53-mediated apoptosis, angiogenesis, and antioxidant and protection-related proteins, and the downregulations of NFkB signaling proteins, inflammatory proteins, and oncogenic proteins in mouse livers. These protein expression changes induced by DCE were usually limited to the range ± 10%, suggesting murine hepatocytes were safely reactive to DCE within the threshold of physiological homeostasis. DCE-2.5 and DCE-5 induced relatively mild dose-dependent changes in protein expressions for cellular regeneration and de novo angiogenesis as compared with non-treated controls, whereas DCE-10 induced fluctuations in protein expressions.
Conclusion: These observations suggested that DCE-2.5 and DCE-5 were safer and more beneficial to murine hepatocytes than DCE-10. It was also found that murine hepatocytes treated with DCE showed mild p53- mediated apoptosis, followed by cellular proliferation and growth devoid of fibrosis signaling (as determined by IP-HPLC), and subsequently progressed to rapid cellular regeneration and wound healing in the absence of any inflammatory reaction based on histologic observations.
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참고문헌 (36)
참고문헌 신청
Ludwig IA / 2014 / Coffee:biochemistry and potential impact on health / Food Funct 5:1695~1717
Cornelis MC / 2016 / Genome-wide association study of caffeine metabolites provides new insights to caffeine metabolism and dietary caffeine-consumption behavior / Hum Mol Genet 25(24):5472~5482
Zulli A / 2016 / Caffeine and cardiovascular diseases: critical review of current research / Eur J Nutr 55:1331~1343
Cavin C / 2001 / Protective effects of coffee diterpenes against aflatoxin B1-induced genotoxicity: mechanisms in rat and human cells / Food Chem Toxicol 39:549~556
Kim JY / 2004 / The coffee diterpene kahweol suppress the inducible nitric oxide synthase expression in macrophages / Cancer Lett 213:147~154
Cornelis MC / 2016 / Genome-wide association study of caffeine metabolites provides new insights to caffeine metabolism and dietary caffeine-consumption behavior / Hum Mol Genet 25(24):5472~5482
Zulli A / 2016 / Caffeine and cardiovascular diseases: critical review of current research / Eur J Nutr 55:1331~1343
Cavin C / 2001 / Protective effects of coffee diterpenes against aflatoxin B1-induced genotoxicity: mechanisms in rat and human cells / Food Chem Toxicol 39:549~556
Kim JY / 2004 / The coffee diterpene kahweol suppress the inducible nitric oxide synthase expression in macrophages / Cancer Lett 213:147~154
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