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논문 기본 정보

자료유형
학술저널
저자정보
전재호 (서울대학교) 김민균 (국립암센터) 박주영 (국립암센터국제암대학원대학교) 이종호 (서울대학교) 김명진 (서울대학교) 명훈 (서울대학교) 최성원 (국립암센터)
저널정보
대한악안면성형재건외과학회 Maxillofacial Plastic Reconstructive Surgery Maxillofacial Plastic Reconstructive Surgery 제39권 제12호
발행연도
2017.12
수록면
1 - 7 (7page)
DOI
https://doi.org/10.1186/s40902-017-0139-8

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Background The incidence of tongue squamous cell carcinoma (TSCC) in young patients has recently increased, and these TSCCs are believed to be etiologically distinct from those in older patients, who have longer exposure to risk factors such as tobacco and alcohol. The prognosis of TSCCs in young patients remains controversial. Methods We retrospectively reviewed the records of 117 patients (2001?2011) who were diagnosed with squamous cell carcinoma of the oral tongue. Patients were divided into two age groups, older (ages over 40) and younger (ages 40 and younger). Data were compared between the two groups, and survival rates were analyzed. Results The results show that there are significant differences in overall, disease-free, and distant metastasis-free survival rates between the two groups. Five-year overall survival rates were 70% in older patients and 42% in young patients (p?=?0.033). Five-year disease-free survival rates were 73% in older patients and 40% in young patients (p?=?0.011), and 5-year distant metastasis-free survival rates were 97% in older patients and 62% in young patients (p?=?0.033). Multivariate analysis revealed that histologic grade was the only independent risk factor for overall survival in both groups of patients (p?=?0.002, HR?=?2.287). The analysis also demonstrated that age was the critical risk factor for distant metastasis (p?=?0.046, HR?=?9.687). Conclusion In this study, young (ages 40 and younger) patients with squamous cell carcinoma of the oral tongue had a higher rate of distant metastasis and a worse prognosis. Accordingly, we propose the necessity of an extensive therapeutic regimen that should be used in all young patients with TSCC.

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