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논문 기본 정보

자료유형
학술저널
저자정보
Jang Hyo-Jeong (Department of Pediatrics Keimyung University School of Medicine Daegu Korea.) Suh Hyo Rim (Department of Pediatrics School of Medicine Kyungpook National University Daegu Korea.) Choi Sujin (Department of Pediatrics School of Medicine Kyungpook National University Daegu Korea.) Hong Suk Jin (Department of Pediatrics Daegu Catholic University School of Medicine Daegu Korea.) Cho Seung-Man (Department of Pediatrics Dongguk University School of Medicine Gyeongju Korea.) Choi Kwang-Hae (Department of Pediatrics Yeungnam University School of Medicine Daegu Korea.) Choe Byung-Ho (Department of Pediatrics School of Medicine Kyungpook National University Daegu Korea.) Kang Ben (Department of Pediatrics School of Medicine Kyungpook National University Daegu Korea.) Crohn's and Colitis Association in Daegu-Gyeongbuk (Crohn's and Colitis Association in Daegu-Gyeongbuk)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.44
발행연도
2021.11
수록면
1 - 9 (9page)
DOI
10.3346/jkms.2021.36.e278

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Background: There are limited data regarding the extraintestinal manifestations (EIMs) associated with pediatric inflammatory bowel disease (IBD) in Korea. We aimed to investigate the clinical features and factors associated with the development of EIMs in Korean children and adolescents with IBD. Methods: This multicenter, retrospective study was conducted from 2010 to 2017. Baseline clinicodemographic, laboratory findings, disease activity, disease phenotypes, and EIMs were investigated. Results: A total of 172 patients were included. One-hundred thirty-seven (79.7%) had Crohn's disease (CD), and 35 (20.3%) had ulcerative colitis (UC). EIMs occurred in 42 patients (24.4%). EIMs developed in 34/137 diagnosed with CD (24.8%), and in 8/35 diagnosed with UC (22.9%), during a median follow-up duration of 3.2 (interquartile range, 1.9?5.4) years for CD and 3.0 (1.0?4.0) years for UC, respectively. Arthritis/arthralgia was most commonly observed (n = 15, 35.7%), followed by stomatitis/oral ulcer (n = 10, 23.8%), hepatitis (n = 5, 11.9%), nephritis (n = 4, 9.5%), pancreatitis (n = 2, 4.8%), erythema nodosum (n = 2, 4.8%), pyoderma gangrenosum (n = 1, 2.4%), primary sclerosing cholangitis (n = 1, 2.4%), uveitis (n = 1, 2.4%), and ankylosing spondylitis (n = 1, 2.4%). A significant difference in disease severity based on the Paris classification (P = 0.011) and ESR at diagnosis (P = 0.043) was observed between the EIM positive and negative group in patients with UC. According to logistic regression analyses, S1 disease severity based on the Paris classification was the only factor that was significantly associated with the development of EIMs (odds ratio, 16.57; 95% confidence interval, 2.18?287.39; P = 0.017). Conclusion: Severe disease activity based on the Paris classification in pediatric patients with UC was significantly associated with EIM development. As disease severity in the Paris classification is a dynamic parameter, treatment should be focused on disease control to minimize the occurrence of EIMs in Korean children and adolescents with UC.
#Extraintestinal Manifestation #Crohn's Disease #Ulcerative Colitis #Pediatric #Paris Classification

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참고문헌 (23)

참고문헌 신청
Rosen MJ / 2015 / Inflammatory bowel disease in children and adolescents / JAMA Pediatr 169(11):1053~1060 google schola Jose FA / 2008 / Extraintestinal manifestations of inflammatory bowel disease / J Pediatr Gastroenterol Nutr 46(2):124~133 google schola Veloso FT / 2011 / Extraintestinal manifestations of inflammatory bowel disease : do they influence treatment and outcome / World J Gastroenterol 17(22):2702~2707 google schola Jose FA / 2009 / Development of extraintestinal manifestations in pediatric patients with inflammatory bowel disease / Inflamm Bowel Dis 15(1):63~68 google schola Hyams JS / 1994 / Extraintestinal manifestations of inflammatory bowel disease in children / J Pediatr Gastroenterol Nutr 19(1):7~21 google schola

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