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논문 기본 정보

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학술저널
저자정보
Jeung Min Sub (Department of Pediatrics Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Ko) Kim Mi Jin (Department of Pediatrics Asan Medical Center Seoul Korea.) Huh June (Department of Pediatrics Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Ko) Kang I-Seok (Department of Pediatrics Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Ko) Kim Gi Beom (Department of Pediatrics Seoul National University Children's Hospital Seoul Korea.) Yu Jeong Jin (Department of Pediatrics Asan Medical Center Seoul Korea.) Song Jinyoung (Department of Pediatrics Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Ko)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.44
발행연도
2021.11
수록면
1 - 9 (9page)
DOI
10.3346/jkms.2021.36.e283

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Background: Despite advancements in heart transplantation for pediatric patients in Korea, the waiting list mortality has not been reported. Therefore, we investigated the waiting list mortality rate and factors associated with patient mortality. Methods: We reviewed the medical records of pediatric patients who were registered for heart transplantation at three major hospitals in Korea from January 2000 to January 2020. All patients who died while waiting for heart transplantation were investigated, and we identified the waiting list mortality rate, causes of mortality and the median survival periods depending on the variable risk factors. Results: A total of 145 patients received heart transplantations at the three institutions we surveyed, and the waiting list mortality rate was 26%. The most common underlying diseases were cardiomyopathy (66.7%) and congenital heart disease (30.3%). The leading causes that contributed to death were heart failure (36.3%), multi-organ failure (27.2%), and complications associated with extracorporeal membrane oxygenation (ECMO) (25.7%). The median survival period was 63 days. ECMO was applied in 30 patients. The different waiting list mortality percentages according to age, cardiac diagnosis, use of ECMO, and initial Korean Network of Organ Sharing (KONOS) level were determined using univariate analysis, but age was the only significant factor associated with waiting list mortality based on a multivariate analysis. Conclusion: The waiting list mortality of pediatric heart transplantation candidates was confirmed to be considerably high, and age, underlying disease, the application of ECMO, and the initial KONOS level were the factors that influenced the survival period.
#Heart Transplantation #Pediatrics #Waiting Lists #Mortality

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참고문헌 (17)

참고문헌 신청
Almond CS / 2009 / Waiting list mortality among children listed for heart transplantation in the United States / Circulation 119(5):717~727 google schola Shimizu M / 2016 / Outcomes in children with advanced heart failure in Japan : importance of mechanical circulatory support / Heart Vessels 31(7):1162~1167 google schola Smits JM / 2014 / Pediatric heart allocation and transplantation in Eurotransplant / Transpl Int 27(9):917~925 google schola Mah D / 2009 / Incidence and risk factors for mortality in infants awaiting heart transplantation in the USA / J Heart Lung Transplant 28(12):1292~1298 google schola Jeewa A / 2014 / Risk factors for mortality or delisting of patients from the pediatric heart transplant waiting list / J Thorac Cardiovasc Surg 147(1):462~468 google schola

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