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논문 기본 정보

자료유형
학술저널
저자정보
Yoon Hee-Young (Department of Pulmonary and Critical Care Medicine Asan Medical Center University of Ulsan College) Lee Suk Hyun (Department of Nuclear Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Ko) Ha Sejin (Department of Nuclear Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Ko) Ryu Jin-Sook (Department of Nuclear Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Ko) Song Jin Woo (Department of Pulmonary and Critical Care Medicine Asan Medical Center University of Ulsan College)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.41
발행연도
2021.10
수록면
1 - 13 (13page)
DOI
10.3346/jkms.2021.36.e257

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Background: Several parameters are useful for assessing disease severity in idiopathic pulmonary fibrosis (IPF); however, the role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is not well-defined. We aimed to evaluate the value of 18F-FDG PET/CT for assessing disease severity and prognosis in IPF patients. Methods: Clinical data of 89 IPF patients (mean age: 68.1 years, male: 94%) who underwent 18F-FDG PET/CT for evaluation of lung nodules or cancer staging were retrospectively reviewed. Mean and maximal standardized uptake values (SUVmean, SUVmax, respectively) were measured in the fibrotic area. Adjusted SUV, including SUV ratio (SUVR, defined as SUVmaxto-liver SUVmean ratio), tissue fraction-corrected SUVmean (SUVmeanTF), and SUVR (SUVRTF), and tissue-to-blood ratio (SUVmax/SUVmean venous; TBRblood) were obtained. Death was defined as the primary outcome, and associations between other clinical parameters (lung function, exercise capacity, C-reactive protein [CRP] level) were also investigated. Results: All SUV parameters were inversely correlated with the forced vital capacity, diffusing capacity for carbon monoxide, and positively correlated with CRP level and the gender-agephysiology index. The SUVmean, SUVmax, and SUVmeanTF were associated with changes in lung function at six months. The SUVR (hazard ratio [HR], 1.738; 95% confidence interval [CI], 1.011?2.991), SUVRTF (HR, 1.441; 95% CI, 1.000?2.098), and TBRblood (HR, 1.377; 95% CI, 1.038?1.827) were significant predictors for mortality in patients with IPF in the univariate analysis, but not in the multivariate analysis. Conclusion: 18F-FDG PET/CT may provide additional information on the disease severity and prognosis in IPF patients, and the SUVR may be superior to other SUV parameters.

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