지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.8
- 수록면
- 1 - 10 (10page)
- DOI
- 10.3346/jkms.2021.36.e217
이용수
초록· 키워드
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Background: Bacterial infections are well known factors underlying acute exacerbations in bronchiectasis. However, viral infections may also contribute to acute exacerbations. We aimed to assess the rate of viral detection in acute exacerbations of bronchiectasis, and the associated clinical factors.
Methods: Diagnostic tests for viral and bacterial etiologies were performed in 792 patients with bronchiectasis who visited the emergency room or the respiratory care inpatient unit in a tertiary referral center in South Korea. All patients were diagnosed with bronchiectasis by chest computerized tomography and were prescribed antibiotics for a minimum of 3 days.
Results: Viral pathogens were detected in 202 of the 792 enrolled patients (25.5%). The most common viral pathogen isolated was influenza A virus (24.8%), followed by rhinovirus (22.4%), influenza B virus (9.8%), respiratory syncytial virus B (8.9%), and human metapneumovirus (6.1%). In 145 patients, a viral, but not bacterial, pathogen was detected, whereas no pathogens were found in 443 patients with exacerbations. Multivariable analysis revealed that female sex and chronic heart disease as a comorbidity were positively associated with viral detection in acute exacerbations of patients with bronchiectasis, whereas the presence of radiographic infiltration was negatively associated.
Conclusion: Respiratory viruses were identified in approximately 25% of the acute exacerbations observed among patients with bronchiectasis. Of the viruses detected, influenza viruses and rhinovirus made up over 50%. More attention to viruses as possible causative pathogens for acute deteriorating symptoms in patients with bronchiectasis is warranted.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Chalmers JD / 2014 / The bronchiectasis severity index. An international derivation and validation study / Am J Respir Crit Care Med 189(5):576~585
Loebinger MR / 2009 / Mortality in bronchiectasis : a long-term study assessing the factors influencing survival / Eur Respir J 34(4):843~849
Gao YH / 2015 / The role of viral infection in pulmonary exacerbations of bronchiectasis in adults : a prospective study / Chest 147(6):1635~1643
Murray PR / 1975 / Microscopic and baceriologic analysis of expectorated sputum / Mayo Clin Proc 50(6):339~344
Shek LP / 2003 / Epidemiology and seasonality of respiratory tract virus infections in the tropics / Paediatr Respir Rev 4(2):105~111
Loebinger MR / 2009 / Mortality in bronchiectasis : a long-term study assessing the factors influencing survival / Eur Respir J 34(4):843~849
Gao YH / 2015 / The role of viral infection in pulmonary exacerbations of bronchiectasis in adults : a prospective study / Chest 147(6):1635~1643
Murray PR / 1975 / Microscopic and baceriologic analysis of expectorated sputum / Mayo Clin Proc 50(6):339~344
Shek LP / 2003 / Epidemiology and seasonality of respiratory tract virus infections in the tropics / Paediatr Respir Rev 4(2):105~111
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