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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 1,327 - 1,337 (11page)
- DOI
- 10.1007/s13258-021-01129-5
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초록· 키워드
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Background The Gram-negative intracellular bacterium Mycoplasma anatis is a pathogen of respiratory infectious diseases in ducks and has caused signifcant economic losses in the poultry industry.
Objective This study, as the frst report of the structure and function of the pan-genome of Mycoplasma anatis, may provide a valuable genetic basis for many aspects of future research on the pathogens of waterfowl.
Methods We sequenced the whole genomes of 15 Mycoplasma anatis isolated from ducks in China. Draft genome sequencing was carried out and whole-genome sequencing was performed by the sequencers of the PacBio Sequel and an IonTorrent Personal Genome Machine (PGM). Then the common genic elements of protein-coding genes, tRNAs, and rRNAs of Mycoplasma anatis genomes were predicted by using the pipeline Prokka v1.13.7. To investigate homologous protein clusters across Mycoplasma anatis genomes, we adopted Roary v3.13.0 to cluster orthologous genes (OGs) based on the following criteria.
Results We obtained one complete genome and 14 genome sketches. Microbial mobile genetic element analysis revealed the distribution of insertion sequences (IS30, IS3, and IS1634), prophage regions, and CRISPR arrays in the genome of Mycoplasma anatis. Comparative genomic analysis decoded the genetic components and functional classifcation of the pan-genome of Mycoplasma anatis that comprised 646 core genes, 231 dispensable genes and among them 110 was strainspecifc. Virulence-related gene profles of Mycoplasma anatis were systematically identifed, and the products of these genes included bacterial ABC transporter systems, iron transport proteins, toxins, and secretion systems.
Conclusion A complete virulence-related gene profle of Mycoplasma anatis has been identifed, most of the genes are highly conserved in all strains. Sequencing results are relevant to the molecular mechanisms of drug resistance, adaptive evolution of pathogens, population structure, and vaccine development.
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참고문헌 (37)
참고문헌 신청
Adams JJ / 2008 / Structural basis of Clostridium perfringens toxin complex formation / Proc Natl Acad Sci USA 105(34):12194~12199
Altschul SF / 1997 / Gapped BLAST and PSI BLAST : a new generation of protein database search programs / Nucl Acids Res 25:3389~3402
Bankevich A / 2012 / SPAdes : a new genome assembly algorithm and its applications to single-cell sequencing / J Comput Biol 19(5):455~477
Bencina D / 1988 / Natural infection of ducks with Mycoplasma synoviae and Mycoplasma gallisepticum and Mycoplasma egg transmission / Avian Pathol 17(2):441~449
Bland C / 2007 / CRISPR recognition tool(CRT) : a tool for automatic detection of clustered regularly interspaced palindromic repeats / BMC Bioinform 8(1):209
Altschul SF / 1997 / Gapped BLAST and PSI BLAST : a new generation of protein database search programs / Nucl Acids Res 25:3389~3402
Bankevich A / 2012 / SPAdes : a new genome assembly algorithm and its applications to single-cell sequencing / J Comput Biol 19(5):455~477
Bencina D / 1988 / Natural infection of ducks with Mycoplasma synoviae and Mycoplasma gallisepticum and Mycoplasma egg transmission / Avian Pathol 17(2):441~449
Bland C / 2007 / CRISPR recognition tool(CRT) : a tool for automatic detection of clustered regularly interspaced palindromic repeats / BMC Bioinform 8(1):209
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