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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 446 - 453 (8page)
- DOI
- 10.5668/JEHS.2021.47.5.446
이용수
초록· 키워드
오류제보하기
Background: Plastic particles less than 5 mm in diameter (microplastics) are well-known for causing various toxicities such as lung inflammation, oxidative stress, genotoxicity, and reproductive toxicity. As microplastics become smaller, they can move across cell membranes, the placenta, and the blood-brain barrier.
Objectives: We evaluated the toxicities of polyethylene microplastics (PE-PMs) in dams and neonates through intragastric intubation of pregnant ICR mice.
Methods: Low concentrations (0.01 mg/mouse/day) and high concentrations (0.1 mg/mouse/day) of polyethylene microplastics were administered from the ninth day of pregnancy to postnatal day seven. The control group was administered with distilled water. On the day of sacrifice, the weight of dams and neonates and the organ weight of neonates was measured. Further, acetylcholinesterase levels and glutathione peroxidase levels were evaluated by using a blood sample obtained on the sacrifice day.
Results: No significant difference in the number of neonates was found, but the body weight gain of dams was seen to be lower in the low-dose group. On the other hand, we observed a consecutively declining trend in the weight gain and organ weight of neonates among the high-, control, and low-dose groups. Meanwhile, the serum acetylcholinesterase and glutathione peroxidase level were higher in the low-dose group compared to the control group. Further, the dose-dependent accumulation of microplastics in the organs of neonates revealed the transport of plastic particles from dams to their offspring.
Conclusions: Although the exact mechanism of toxicity caused by microplastics could not be confirmed, it was validated that exposure to microplastics during pregnancy and lactation causes its migration between generations and accumulation throughout the body. Hence, it is necessary to evaluate the systemic toxicity of microplastics and assessment of co-morbidities such as second-generation toxicity, neurotoxicity, and depression following long-term exposure.
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참고문헌 (31)
참고문헌 신청
Abbasi S / 2019 / Distribution and potential health impacts of microplastics and microrubbers in air and street dusts from Asaluyeh County, Iran / Environ Pollut 244:153~164
Dris R / 2016 / Synthetic fibers in atmospheric fallout: a source of microplastics in the environment? / Mar Pollut Bull 104(1-2):290~293
Woodall LC / 2015 / Using a forensic science approach to minimize environmental contamination and to identify microfibres in marine sediments / Mar Pollut Bull 95(1):40~46
Napper IE / 2015 / Characterisation, quantity and sorptive properties of microplastics extracted from cosmetics / Mar Pollut Bull 99(1-2):178~185
Huerta Lwanga E / 2016 / Microplastics in the terrestrial ecosystem : implications for lumbricus terrestris(Oligochaeta, Lumbricidae) / Environ Sci Technol 50(5):2685~2691
Dris R / 2016 / Synthetic fibers in atmospheric fallout: a source of microplastics in the environment? / Mar Pollut Bull 104(1-2):290~293
Woodall LC / 2015 / Using a forensic science approach to minimize environmental contamination and to identify microfibres in marine sediments / Mar Pollut Bull 95(1):40~46
Napper IE / 2015 / Characterisation, quantity and sorptive properties of microplastics extracted from cosmetics / Mar Pollut Bull 99(1-2):178~185
Huerta Lwanga E / 2016 / Microplastics in the terrestrial ecosystem : implications for lumbricus terrestris(Oligochaeta, Lumbricidae) / Environ Sci Technol 50(5):2685~2691
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