Biodistribution study of orally administered microplastics: PET/CT study

Jang Woo Park; Heejung Kim; Eun Sang Lee; Yiseul Choi; Hye Kyung Chung; Jae Hoon Shim

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자료유형: 학술대회자료

저자정보: Jang Woo Park (Korea Institute of Radiological & Medical Sciences) Heejung Kim (Korea Institute of Radiological & Medical Sciences) Eun Sang Lee (Korea Institute of Radiological & Medical Sciences) Yiseul Choi (Korea Institute of Radiological & Medical Sciences) Hye Kyung Chung (Korea Institute of Radiological & Medical Sciences) Jae Hoon Shim (Korea Institute of Radiological & Medical Sciences)

저널정보: 한국실험동물학회 한국실험동물학회 학술발표대회 논문집 2021년 한국실험동물학회 국제학술대회 [초록집]

발행연도: 2021.7

수록면: 223 - 223 (1page)

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이 논문의 연구 히스토리 (2)

2022

Biodistribution study of microplastics in mouse following intratracheal instillation by PET/CT

Jang Woo Pa , k , Eun Sang Lee 외 5명 한국실험동물학회 학술발표대회 논문집 2022.07 학술대회자료

2021

Biodistribution study of orally administered microplastics: PET/CT study

Jang Woo Pa , k , Heejung Kim 외 4명 한국실험동물학회 학술발표대회 논문집 2021.07 학술대회자료

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Introduction: Microplastics are generated through processes such as photolysis, weathering, and abrasion of waste plastics that are discarded or left unattended after use. Recently, as microplastics have been discovered in living organisms and foods consumed by humans, related research is rapidly increasing with the main interest in toxicology and environmental sciences. Assessing the behavior of microplastics ingested with food is important to understanding the potential toxicity of microplastics in the body. PET/CT images using radioactive isotopes in behavioral evaluation have the advantage of being quantitatively evaluated. In this study, dynamic PET/CT images were acquired using orally administered microplastics (64Cu-PVC) and the behavior of microplastics in the body was evaluated.
Method: ICR mouse was used to evaluate the behavior of microplastics. For PET/CT image acquisition, nano PET/CT (Mediso, Budapest, Hungary) was used and anesthetized with oxygen containing 2.0-2.5% isoflurane during image acquisition. Then, labeling the microplastic (PVC, ≤1um) bound with NH2-NODA-GA with 64Cu (t1/2=12.7hr), was orally administered by^_@span style=color:#999999 ^_# ... ^_@/span^_#^_@a href=javascript:; onclick=onClickReadNode('NODE10618178');fn_statistics('Z354','null','null'); style='color:#999999;font-size:14px;text-decoration:underline;' ^_#전체 초록 보기^_@/a^_#

#Microplastics #PET/CT #Oral administration

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