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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제9호
- 발행연도
- 2021.9
- 수록면
- 1,272 - 1,280 (9page)
- DOI
- 10.4014/jmb.2106.06043
이용수
초록· 키워드
오류제보하기
With changes in human dietary patterns, the proportion of high-fat and high-cholesterol foods in the daily diet has increased. As a result, the incidence rate of cholelithiasis is increasing rapidly.
Many studies have reported on the crucial role that the intestinal microflora plays in the progression of gallstones. Although the whole herb of Lysimachia christinae, a traditional Chinese medicine, has long been extensively used as a remedy for cholelithiasis in China, its effects on the intestinal microflora remain unknown. Hence, in this study, we investigated the ability of the aqueous extract of L. christinae (LAE) to prevent cholesterol gallstones (CGSs) in model animals by affecting the intestinal microflora. The effects of LAE on body weight, serum lipid profile, visceral organ indexes, and histomorphology were studied in male C57BL/6J mice, which were induced by a lithogenic diet.
After the 8-week study, CGSs formation was greatly reduced after LAE treatment. LAE also reduced body weight gain and hyperlipidemia and restored the histomorphological changes. Moreover, the intestinal microflora exhibited significant variation. In the model group fed the lithogenic diet, the abundances of the genera unclassified Porphyromonadaceae, Lactobacillus and Alloprevotella decreased, but in contrast, Akkermansia dramatically increased compared with the control check group, which was fed a normal diet; the administration of LAE reversed these changes. These results imply that L. christinae can be considered an efficient therapy for eliminating CGSs induced by a high-fat and high-cholesterol diet, which may be achieved by influencing the intestinal microflora.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Hu FL / 2021 / Biliary microbiota and mucin 4 impact the calcification of cholesterol gallstones / Hepatobiliary Pancreat. Dis. Int 20:61~66
Deng J / 2015 / Lysimachia christinae Hance regresses preestablished cholesterol gallstone in mice / J. Ethnopharmacol 166:102~108
van Dooren I / 2015 / Cholesterol lowering effect in the gall bladder of dogs by a standardized infusion of Herniaria hirsuta L / J. Ethnopharmacol 169:69~75
Verpoorte R / 2006 / Editorial / J. Ethnopharmacol 103:309~310
Reshetnyak VI / 2012 / Concept of the pathogenesis and treatment of cholelithiasis / World J. Hepatol 4:18~34
Deng J / 2015 / Lysimachia christinae Hance regresses preestablished cholesterol gallstone in mice / J. Ethnopharmacol 166:102~108
van Dooren I / 2015 / Cholesterol lowering effect in the gall bladder of dogs by a standardized infusion of Herniaria hirsuta L / J. Ethnopharmacol 169:69~75
Verpoorte R / 2006 / Editorial / J. Ethnopharmacol 103:309~310
Reshetnyak VI / 2012 / Concept of the pathogenesis and treatment of cholelithiasis / World J. Hepatol 4:18~34
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