지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.10
- 수록면
- 501 - 506 (6page)
이용수
초록· 키워드
오류제보하기
BACKGROUNG/OBJECTIVES: Corn silk (CS) extract contains large amounts of maysin, which is a major flavonoid in CS. However, studies regarding the effect of CS extract on cholesterol metabolism is limited. Therefore, the purpose of this study was to determine the effect of CS extract on cholesterol metabolism in C57BL/6J mouse fed high-fat diets.
MATERIALS/METHODS: Normal-fat group fed 7% fat diet, high-fat (HF) group fed 25% fat diet, and high-fat with corn silk (HFCS) group were orally administered CS extract (100 mg/kg body weight) daily. Serum and hepatic levels of total lipids, triglycerides, and total cholesterol as well as serum free fatty acid, glucose, and insulin levels were determined. The mRNA expression levels of acyl-CoA: cholesterol acyltransferase (ACAT), cholesterol 7-alpha hydroxylase (CYP7A1), farnesoid X receptor (FXR), lecithin cholesterol acyltransferase (LCAT), low-density lipoprotein receptor, 3-hyroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), adiponectin, leptin, and tumor necrosis factor α were determined.
RESULTS: Oral administration of CS extract with HF improved serum glucose and insulin levels as well as attenuated HF-induced fatty liver. CS extracts significantly elevated mRNA expression levels of adipocytokines and reduced mRNA expression levels of HMG-CoA reductase, ACAT, and FXR. The mRNA expression levels of CYP7A1 and LCAT between the HF group and HFCS group were not statistically different.
CONCLUSIONS: CS extract supplementation with a high-fat diet improves levels of adipocytokine secretion and glucose homeostasis. CS extract is also effective in decreasing the regulatory pool of hepatic cholesterol, in line with decreased blood and hepatic levels of cholesterol though modulation of mRNA expression levels of HMG-CoA reductase, ACAT, and FXR.
MATERIALS/METHODS: Normal-fat group fed 7% fat diet, high-fat (HF) group fed 25% fat diet, and high-fat with corn silk (HFCS) group were orally administered CS extract (100 mg/kg body weight) daily. Serum and hepatic levels of total lipids, triglycerides, and total cholesterol as well as serum free fatty acid, glucose, and insulin levels were determined. The mRNA expression levels of acyl-CoA: cholesterol acyltransferase (ACAT), cholesterol 7-alpha hydroxylase (CYP7A1), farnesoid X receptor (FXR), lecithin cholesterol acyltransferase (LCAT), low-density lipoprotein receptor, 3-hyroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), adiponectin, leptin, and tumor necrosis factor α were determined.
RESULTS: Oral administration of CS extract with HF improved serum glucose and insulin levels as well as attenuated HF-induced fatty liver. CS extracts significantly elevated mRNA expression levels of adipocytokines and reduced mRNA expression levels of HMG-CoA reductase, ACAT, and FXR. The mRNA expression levels of CYP7A1 and LCAT between the HF group and HFCS group were not statistically different.
CONCLUSIONS: CS extract supplementation with a high-fat diet improves levels of adipocytokine secretion and glucose homeostasis. CS extract is also effective in decreasing the regulatory pool of hepatic cholesterol, in line with decreased blood and hepatic levels of cholesterol though modulation of mRNA expression levels of HMG-CoA reductase, ACAT, and FXR.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Corn silk extract improves cholesterol metabolism in C57BL/6J mouse fed high-fat diets
Nutrition Research and Practice
2016 .10
-
High maysin corn silk extract reduces body weight and fat deposition in C57BL/6J mice fed high-fat diets
Nutrition Research and Practice
2016 .12
-
High maysin corn silk extract reduces body weight and fat deposition in C57BL/6J mice fed high-fat diets
Nutrition Research and Practice
2016 .12
-
The effects of Brassica juncea L. leaf extract on obesity and lipid profiles of rats fed a high-fat/high-cholesterol diet
Nutrition Research and Practice
2018 .08
-
The effects of Brassica juncea L. leaf extract on obesity and lipid profiles of rats fed a high-fat/high-cholesterol diet
Nutrition Research and Practice
2018 .08
-
Increased Hepatic Lipogenesis Elevates Liver Cholesterol Content
Molecules and Cells
2021 .01
-
The effects of black garlic (Allium satvium) extracts on lipid metabolism in rats fed a high fat diet
Nutrition Research and Practice
2015 .02
-
The effects of black garlic (Allium satvium) extracts on lipid metabolism in rats fed a high fat diet
Nutrition Research and Practice
2015 .02
-
Egg phospholipids exert an inhibitory effect on intestinal cholesterol absorption in mice
Nutrition Research and Practice
2019 .08
-
Egg phospholipids exert an inhibitory effect on intestinal cholesterol absorption in mice
Nutrition Research and Practice
2019 .08
-
옥수수 껍질 분말의 In Vitro 에서의 항산화 특성과 고지방식이로 유도된 Mice의 혈청지질 수준에 미치는 영향
동아시아식생활학회지
2015 .04
-
고지방식이 급여 쥐에서 수용성 뽕나무 잎 추출물의 간 microRNA-221/222 발현 및 염증 조절을 통한 간 지질 축적억제 효과
Journal of Nutrition and Health
2022 .04
-
[Erratum] Effects of disturbed liver growth and oxidative stress of high-fat diet-fed dams on cholesterol metabolism in offspring mice
Nutrition Research and Practice
2017 .10
-
[Erratum] Effects of disturbed liver growth and oxidative stress of high-fat diet-fed dams on cholesterol metabolism in offspring mice
Nutrition Research and Practice
2017 .10
-
Effects of disturbed liver growth and oxidative stress of high-fat diet-fed dams on cholesterol metabolism in offspring mice
Nutrition Research and Practice
2016 .08
-
Effects of disturbed liver growth and oxidative stress of high-fat diet-fed dams on cholesterol metabolism in offspring mice
Nutrition Research and Practice
2016 .08
-
고지방식이 비만 유도 mouse에서 누에체액의 항비만 및 LDL-cholesterol 저하효과
Journal of Nutrition and Health
2018 .06
-
Effect of Lactobacillus rhamnosus BFE5264 on Cholesterol Level and Gut Microbiota in High-cholesterol Diet-fed Mice
한국미생물학회 학술대회논문집
2016 .04
-
증포 횟수를 달리하여 만든 선식을 첨가한 고지방식이가 비만 쥐의 혈당과 염증지표에 미치는 영향
동아시아식생활학회지
2015 .02
-
Korean Curcuma longa L. induces lipolysis and regulates leptin in adipocyte cells and rats
Nutrition Research and Practice
2016 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2017-594-001422137