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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제48권 제6호
- 발행연도
- 2018.11
- 수록면
- 639 - 655 (17page)
- DOI
- 10.1007/s40005-017-0360-6
이용수
초록· 키워드
오류제보하기
Salmonella enterica is an important enteric pathogen that causes intestinal and systemic infections in warm-blooded animals. Due to different problems caused by administration of live attenuated vaccines, a DNA vaccine that is protective against S. enterica is desirable. By combining conserved antigenic determinant into a single vaccine, cross-protective immunity against many different immunogenic serovars can be achieved. This study proposed an in silico approach by assembling antigenic and conserved regions of SopB and GroEL proteins of S. enterica to induce multi-epitopic responses against the pathogen. In total, two unique and reliable antigenic regions of each protein were found and assembled in a chimeric DNA construct fused using appropriate linkers. Epitope predictions showed that the hypothetical synthetic construct could induce B and T-cell epitopes that yield a high immune response. Most regions of the chimeric construct were predicted to have high antigenic propensity and surface accessibility. The three-dimensional structure of the construct was generated and validated as a proper model which may define reliability, structural quality and conformation. DNA vaccine could cause concentration and increasing immune responses to critical epitopes and decrease adverse effects of vaccination.
Successful in silico modeling has shown to be a promising approach to design robust vaccine targeting SopB and GroEL proteins of S. enterica.
목차
등록된 정보가 없습니다.
참고문헌 (66)
참고문헌 신청
Amara RR / 2002 / Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine / Vaccine 20(15):1949~1955
Berzofsky JA / 2001 / Strategies for designing and optimizing new generation vaccines / Nat Rev Immunol 1(3):209~219
Blom N / 1999 / Sequence and structure-based prediction of eukaryotic protein phosphorylation sites / J Mol Biol 294(5):1351~1362
Cai C / 2003 / SVM-Prot: web-based support vector machine software for functional classification of a protein from its primary sequence / Nucl Acids Res 31(13):3692~3697
Chan K / 2003 / Genomic comparison of Salmonella enterica serovars and Salmonella bongori by use of an S. enterica serovar typhimurium DNA microarray / J Bacteriol 185(2):553~563
Berzofsky JA / 2001 / Strategies for designing and optimizing new generation vaccines / Nat Rev Immunol 1(3):209~219
Blom N / 1999 / Sequence and structure-based prediction of eukaryotic protein phosphorylation sites / J Mol Biol 294(5):1351~1362
Cai C / 2003 / SVM-Prot: web-based support vector machine software for functional classification of a protein from its primary sequence / Nucl Acids Res 31(13):3692~3697
Chan K / 2003 / Genomic comparison of Salmonella enterica serovars and Salmonella bongori by use of an S. enterica serovar typhimurium DNA microarray / J Bacteriol 185(2):553~563
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