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Image-guided nanomedicine for cancer
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논문 기본 정보

Type
Academic journal
Author
최종훈 (Texas A&M University) 이용재 (Texas A&M University) 김동인 (Texas A&M University)
Journal
Korean Society of Pharmaceutical Science and Technology Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제47권 제1호 KCI Accredited Journals
Published
2017.1
Pages
51 - 64 (14page)

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Image-guided nanomedicine for cancer
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Abstract· Keywords

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Since current treatment options applicable to cancers are still confined to chemotherapeutics followed by surgical debulking, cancer disease is a second leading cause of death because of chemotherapeutics of non-specific biodistribution. Image-guided drug delivery system (IGDDS) is a real-time noninvasive imaging assessment of therapeutic response that has the strong potential to control or suppress cancer because imaging property offer the quantification of nanomedicine at the intended disease site, thus the potential assurance of adequate treatment and elimination of undesirable delay leading to poor clinical outcomes. Also, combining pH-sensitive advantages of nanoparticle with theranostic property will have high chance to overcome cancer. There have been intensive researches to develop innovative IGDDS by using nanoparticles including organic or inorganic theranostic (therapy + diagnostic) systems including liposomes, polymeric micelles, dendrimers, carbon nanotubes, gold nanoparticles, iron oxide nanoparticles, quantum dots, and silica nanoparticles. In this review, we will introduce various examples of each system and will discuss their theranostic applications.
#Theranostic #Organic nanoparticles #Inorganic nanoparticles #Cancer

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References (102)

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Ahmed N / 2012 / Theranostic applications of nanoparticles in cancer / Drug Discov Today 17:928~934 google schola Akerman ME / 2002 / Nanocrystal targeting in vivo / Proc Natl Acad Sci 99:12617~12621 google schola Alqawlaq S / 2014 / Preclinical development and ocular biodistribution of gemini-DNA nanoparticles after intravitreal and topical administration: towards non-invasive glaucoma gene therapy / Nanomed Nanotech Biol Med 10:1637~1647 google schola Benezra M / 2011 / Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma / J Clin Invest 121:2768~2780 google schola Berry CC / 2003 / Dextran and albumin derivatised iron oxide nanoparticles: influence on fibroblasts in vitro / Biomaterials 24:4551~4557 google schola

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