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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.10
- 수록면
- 2,410 - 2,414 (5page)
- DOI
- https://doi.org/10.1016/j.net.2020.03.010
이용수
초록· 키워드
오류제보하기
Heavy ions have a high potential for destroying deep tumors that carry the highest dose at the peak of Bragg. The peak caused by a single-energy carbon beam is too narrow, which requires special measures for improvement. Here, carbon-12 (12C) ion with different energies has been used as a source for calculating the dose distribution in the water phantom, soft tissue and bone by the code of Monte Carlo-based FLUKA code. By increasing the energy of the initial beam, the amount of absorbed dose at Bragg peak in all three targets decreased, but the trend for this reduction was less severe in bone. While the maximum absorbed dose per bone-mass unit in energy of 200 MeV/u was about 30% less than the maximum absorbed dose per unit mass of water or soft tissue, it was merely 2.4% less than soft tissue in 400 MeV/u. The simulation result showed a good agreement with experimental data at GSI Darmstadt facility of biophysics group by 0.15 cm average accuracy in Bragg peak positioning. From 200 to 400 MeV/u incident energy, the Bragg peak location increased about 18 cm in soft tissue. Correspondingly, the bone and soft tissue revealed a reduction dose ratio by 2.9 and 1.9. Induced neutrons did not contribute more than 1.8% to the total energy deposited in the water phantom. Also during 12C ion bombardment, secondary fragments showed 76% and 24% of primary 200 and 400 MeV/u, respectively, were present at the Bragg-peak position. The combined treatment of carbon ions with neutron or electron beams may be more effective in local dose delivery and also treating malignant tumors.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
J. Soltani-Nabipour / 2010 / Residual nuclides produced by 290 MeV/u 12C ions beam in a liquid water target / Rom. Rep. Phys 62(1):37~46
A. Khorshidi / 2014 / Low energy electron generator design and depth dose prediction for microsuperficies tumors treatment purposes / Phys. Scripta 89(9):095001
P. Azimi / 2016 / Proton therapy in neurosurgery : a historical review and future perspective based on currently available new generation systems / Int. J. Clin. Neurosci 3(2):59~80
S. Malmir / 2017 / Enhancement evaluation of energy deposition and secondary particle production in gold nanoparticle aided tumor using proton therapy / Int. J. Canc. Manag 10(10):e10719
G. L. Campos / 2019 / Proposed parameters for a circular particle accelerator for proton beam therapy obtained by genetic algorithm / Braz J. Radiol. Sci 2(7):1~15
A. Khorshidi / 2014 / Low energy electron generator design and depth dose prediction for microsuperficies tumors treatment purposes / Phys. Scripta 89(9):095001
P. Azimi / 2016 / Proton therapy in neurosurgery : a historical review and future perspective based on currently available new generation systems / Int. J. Clin. Neurosci 3(2):59~80
S. Malmir / 2017 / Enhancement evaluation of energy deposition and secondary particle production in gold nanoparticle aided tumor using proton therapy / Int. J. Canc. Manag 10(10):e10719
G. L. Campos / 2019 / Proposed parameters for a circular particle accelerator for proton beam therapy obtained by genetic algorithm / Braz J. Radiol. Sci 2(7):1~15
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