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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 467 - 477 (11page)
- DOI
- 10.48022/mbl.2107.07008
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초록· 키워드
오류제보하기
Staphylococcus aureus is a well-known pathogen that can cause diseases in humans. It can cause both mild superficial skin infections and serious deep tissue infections, including pneumonia, osteomyelitis, and infective endocarditis. To establish host infection, S. aureus manages a complex regulatory network to control virulence factor production in both temporal and host locations. Among these virulence factors, staphyloxanthin, a carotenoid pigment, has been shown to play a leading role in S. aureus pathogenesis. In addition, staphyloxanthin provides integrity to the bacterial cell membrane and limits host oxidative defense mechanisms. The overwhelming rise of Staphylococcus resistance to routinely used antibiotics has necessitated the development of novel anti-virulence agents to overcome this resistance. This review presents an overview of the chief virulence determinants in S. aureus. More attention will be paid to staphyloxanthin, which could be a possible target for anti-virulence agents.
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등록된 정보가 없습니다.
참고문헌 (109)
참고문헌 신청
Pelz A / 2005 / Structure and biosynthesis of staphyloxanthin from Staphylococcus aureus / J. Biol. Chem 280:32493~32498
Aires de Sousa M / 2004 / Bridges from hospitals to the laboratory: genetic portraits of methicillin-resistant Staphylococcus aureus clones / FEMS Immunol. Med. Microbiol 40:101~111
Muto CA / 2003 / SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and enterococcus / Infect. Control Hosp. Epidemiol 24:362~386
Miller LG / 2008 / Clinical practice: colonization, fomites, and virulence: rethinking the pathogenesis of communityassociated methicillin-resistant Staphylococcus aureus infection / Clin. Infect. Dis 46:752~760
Lowy FD / 1998 / Staphylococcus aureus infections / N. Engl. J. Med 339:520~532
Aires de Sousa M / 2004 / Bridges from hospitals to the laboratory: genetic portraits of methicillin-resistant Staphylococcus aureus clones / FEMS Immunol. Med. Microbiol 40:101~111
Muto CA / 2003 / SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and enterococcus / Infect. Control Hosp. Epidemiol 24:362~386
Miller LG / 2008 / Clinical practice: colonization, fomites, and virulence: rethinking the pathogenesis of communityassociated methicillin-resistant Staphylococcus aureus infection / Clin. Infect. Dis 46:752~760
Lowy FD / 1998 / Staphylococcus aureus infections / N. Engl. J. Med 339:520~532
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