지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.5
- 수록면
- 1 - 10 (10page)
- DOI
- 10.1038/s12276-021-00620-z
이용수
초록· 키워드
오류제보하기
2′-Hydroxycinnamaldehyde (HCA), the active component isolated from the stem bark of Cinnamomum cassia , exerts anticancer effects through multiple mechanisms. We recently determined that HCA inhibits signal transducer and activator of transcription 3 (STAT3) signaling in prostate cancer cells. Because STAT3 overactivation has been closely associated with the development of psoriasis, a chronic autoimmune skin disease, we examined whether HCA ameliorates skin lesions in an imiquimod-induced psoriasis-like mouse model. The results showed that intraperitoneal administration of HCA alleviated imiquimod-induced psoriasis-like dermatitis, epidermal thickening, dermal infiltration of inflammatory cells, and proinflammatory cytokine production. Mechanistically, HCA inhibited pyruvate kinase isozyme M2 and STAT3 signaling, leading to the suppression of T cell activation, Th17 cell differentiation, and keratinocyte hyperproliferation. These results suggest that HCA may be a new treatment for psoriasis and other STAT3-mediated skin disorders, such as infection, inflammation and carcinogenesis.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Highlighted STAT3 as a potential drug target for cancer therapy
BMB Reports
2019 .01
-
Stat2 stability regulation: an intersection between immunity and carcinogenesis
Experimental and Molecular Medicine
2020 .09
-
Effect of {1012} Extension Twins on Microstructure Enhancement of Mg-3Al-1Zn Alloy in Half Channel Angular Extrusion
Metals and Materials International
2015 .01
-
Alternative regulatory mechanism for the maintenance of bone homeostasis via STAT5-mediated regulation of the differentiation of BMSCs into adipocytes
Experimental and Molecular Medicine
2021 .05
-
Regulation of signal transducer and activator of transcription 3 activation by dual-specificity phosphatase 3
BMB Reports
2020 .01
-
Rhododendrin inhibits toll-like receptor-7-mediated psoriasis-like skin inflammation in mice
Experimental and Molecular Medicine
2017 .01
-
참조 테이블 기반 스칼라 곱 알고리즘에 대한 충돌 특성을 이용한 향상된 수평상관분석
정보보호학회논문지
2020 .04
-
Alleviation of imiquimod-induced psoriasis-like symptoms in Rorα-deficient mouse skin
BMB Reports
2023 .05
-
TLR7-dependent eosinophil degranulation links psoriatic skin inflammation to small intestinal inflammatory changes in mice
Experimental and Molecular Medicine
2024 .05
-
Modulation of IL-6 via STAT3 signaling in the EC-18 treated cell
한국생물공학회 학술대회
2015 .04
-
LMO2-LDB1 Transcriptional Mediator Activates STAT3 Signaling via GP130-dimerization in Glioblastoma Stem Cells
한국생물공학회 학술대회
2021 .10
-
Assessment of combinational effect of HCA and other dietary supplements on MDCK cyst for possible ADPKD treatment
한국고분자학회 학술대회 연구논문 초록집
2017 .10
-
Integrated computational approach to the analysis of RNA-seq data reveals new transcriptional regulators of psoriasis
Experimental and Molecular Medicine
2016 .01
-
Pellino1 promotes chronic inflammatory skin disease via keratinocyte hyperproliferation and induction of the T helper 17 response
Experimental and Molecular Medicine
2020 .09
-
The JAK1/STAT3/SOCS3 axis in bone development, physiology, and pathology
Experimental and Molecular Medicine
2020 .08
-
Tracking of the STAT3 signaling pathway for anticancer drug discovery based on localized surface plasmon resonance
한국생물공학회 학술대회
2017 .10
-
p38 mitogen-activated protein kinase contributes to TNFα-induced endothelial tube formation of bone-marrow-derived mesenchymal stem cells by activating the JAK/STAT/TIE2 signaling axis
BMB Reports
2024 .05
-
Kimchi Bacteria Against Human Skin Disorders of Psoriasis and Atopic Dermatitis : A Microbiome Therapeutic New Paradigm
한국생물공학회 학술대회
2018 .10
-
Activated Rac1 regulates the degradation of IκBα and the nuclear translocation of STAT3–NFκB complexes in starved cancer cells
Experimental and Molecular Medicine
2016 .01
-
The Improvement of Skin Inflammation by Taxifolin in Psoriasis Model using TNF-α/IL-17A/IFN-γ Induced HaCaT Cells
한국생물공학회 학술대회
2021 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0