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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
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Many active compounds present in Rhododendron brachycarpum have been used in traditional Oriental medicine for the treatment of various skin diseases. However, the precise mechanism of action of the compounds isolated from R. brachycarpum and their relevance as therapeutics for the treatment of psoriasis remain elusive. In this study, we report that rhododendrin isolated from R. brachycarpum strongly inhibits imiquimod (IMQ)-induced psoriasis-like skin inflammation in mice. We showed that topical treatment with rhododendrin reduces IMQ-induced skin hyperplasia, inflammatory mononuclear cell infiltration and the expression of pro-inflammatory mediators in mouse skin. In addition, we found that rhododendrin inhibits the activation of the TLR-7/NF-κB and mitogen-activated protein kinase pathways in both IMQ-induced psoriasis-like skin inflammation in mice and in normal human epidermal keratinocytes treated with IMQ. These results suggest that rhododendrin has an anti-inflammatory effect and can be used as a therapeutic to fight against psoriasis and other inflammatory skin diseases.
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참고문헌 (27)
참고문헌 신청
Bong AB / 2002 / Imiquimod, a topical immune response modifier, in the treatment of cutaneous metastases of malignant melanoma / Dermatology 205 : 135 ~ 138
Cai Y / 2012 / New insights of T cells in the pathogenesis of psoriasis / Cell Mol Immunol 9 : 302 ~ 309
Clark RA / 2006 / Misbehaving macrophages in the pathogenesis of psoriasis / J Clin Invest 116 : 2084 ~ 2087
De Meyer I / 2012 / Toll-like receptor 7 stimulation by imiquimod induces macrophage autophagy and inflammation in atherosclerotic plaques / Basic Res Cardiol 107 : 269 ~
El Malki K / 2013 / An alternative pathway of imiquimod-induced psoriasis-like skin inflammation in the absence of interleukin-17 receptor a signaling / J Invest Dermatol 13
Cai Y / 2012 / New insights of T cells in the pathogenesis of psoriasis / Cell Mol Immunol 9 : 302 ~ 309
Clark RA / 2006 / Misbehaving macrophages in the pathogenesis of psoriasis / J Clin Invest 116 : 2084 ~ 2087
De Meyer I / 2012 / Toll-like receptor 7 stimulation by imiquimod induces macrophage autophagy and inflammation in atherosclerotic plaques / Basic Res Cardiol 107 : 269 ~
El Malki K / 2013 / An alternative pathway of imiquimod-induced psoriasis-like skin inflammation in the absence of interleukin-17 receptor a signaling / J Invest Dermatol 13
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