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논문 기본 정보

자료유형
학술저널
저자정보
Peyton Lee (Mayo Clinic College of Medicine and Science) Oliveros Alfredo (Mayo Clinic College of Medicine and Science) Choi Doo-Sup (Mayo Clinic College of Medicine and Science) Jang Mi-Hyeon (Mayo Clinic College of Medicine and Science)
저널정보
대한생화학·분자생물학회 Experimental and Molecular Medicine Experimental and Molecular Medicine 제53권
발행연도
2021.3
수록면
1 - 11 (11page)
DOI
10.1038/s12276-021-00587-x

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초록· 키워드

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Psychiatric illness is a prevalent and highly debilitating disorder, and more than 50% of the general population in both middle- and high-income countries experience at least one psychiatric disorder at some point in their lives. As we continue to learn how pervasive psychiatric episodes are in society, we must acknowledge that psychiatric disorders are not solely relegated to a small group of predisposed individuals but rather occur in significant portions of all societal groups. Several distinct brain regions have been implicated in neuropsychiatric disease. These brain regions include corticolimbic structures, which regulate executive function and decision making (e.g., the prefrontal cortex), as well as striatal subregions known to control motivated behavior under normal and stressful conditions. Importantly, the corticolimbic neural circuitry includes the hippocampus, a critical brain structure that sends projections to both the cortex and striatum to coordinate learning, memory, and mood. In this review, we will discuss past and recent discoveries of how neurobiological processes in the hippocampus and corticolimbic structures work in concert to control executive function, memory, and mood in the context of mental disorders.

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