지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.9
- 수록면
- 1 - 21 (21page)
- DOI
- 10.1038/s12276-020-00504-8
이용수
초록· 키워드
오류제보하기
As knowledge of cell metabolism has advanced, glutamine has been considered an important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study provided a new perspective on mitochondrial glutamine metabolism, offering mechanistic insights into metabolic adaptation during tumor hypoxia, the emergence of drug resistance, and glutaminolysis-induced metabolic reprogramming and presenting metabolic strategies to target glutamine metabolism in cancer cells. In this review, we introduce the various biosynthetic and bioenergetic roles of glutamine based on the compartmentalization of glutamine metabolism to explain why cells exhibit metabolic reliance on glutamine. Additionally, we examined whether glutamine derivatives contribute to epigenetic regulation associated with tumorigenesis. In addition, in discussing glutamine transporters, we propose a metabolic target for therapeutic intervention in cancer.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Targeting glutamine metabolism as a therapeutic strategy for cancer
Experimental and Molecular Medicine
2023 .04
-
Substitution of Glutamine by Glutamate and Alanyl-glutamine to Reduce Ammonia Production in Transgenic Rice Cell Cultures
한국생물공학회 학술대회
2015 .10
-
Q-SHINE: A Versatile Sensor for Glutamine Measurement via Ligand-induced Dimerization
한국생물공학회 학술대회
2023 .10
-
Effect of pH and glutamine on lactate metabolism in Chinese hamster ovary cell cultures
한국생물공학회 학술대회
2019 .04
-
Glutamine synthetase mediates sorafenib sensitivity in β-catenin-active hepatocellular carcinoma cells
Experimental and Molecular Medicine
2018 .01
-
Amino acids in cancer
Experimental and Molecular Medicine
2020 .01
-
Investigation of metabolic reprograming in CKX-overexpressed colon cancer cells by carbon isotope using GC/MS
한국생물공학회 학술대회
2017 .10
-
Glutamine-derived aspartate is required for eIF5A hypusination-mediated translation of HIF-1α to induce the polarization of tumor-associated macrophages
Experimental and Molecular Medicine
2024 .05
-
Systems Biology of Yeast Metabolism
한국생물공학회 학술대회
2021 .10
-
Prediction of Treatment Targets for Cancer Patients with Poor Prognosis by Using Personalized Genome-Scale Metabolic Models
한국생물공학회 학술대회
2023 .10
-
Resveratrol enhances cisplatin-induced apoptosis in human hepatoma cells via glutamine metabolism inhibition
BMB Reports
2018 .01
-
Systematic Characterization of Metabolic Reprogramming in Cancers Using Genome-scale Metabolic Models
한국생물공학회 학술대회
2021 .10
-
The unique metabolism of Archaea and its potential as a platform for metabolic engineering
한국생물공학회 학술대회
2016 .10
-
A guide to 13C metabolic flux analysis for the cancer biologist
Experimental and Molecular Medicine
2018 .01
-
ROS homeostasis and metabolism: a critical liaison for cancer therapy
Experimental and Molecular Medicine
2016 .01
-
Review of Current Approaches for Implementing Metabolic Reconstruction
바이오시스템공학(구 한국농업기계학회지)
2018 .01
-
Procedure for Developing Metabolic Network Model in Metabolic Reconstruction: a Review
한국생물공학회 학술대회
2017 .04
-
Cancer stem cell metabolism: target for cancer therapy
BMB Reports
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0