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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.8
- 수록면
- 762 - 770 (9page)
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초록· 키워드
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Adiponectin, a hormone produced by adipose tissue, is very abundant in plasma, and its anti- and pro-inflammatory effects are reported. However, the mechanisms of these pro- and anti-inflammatory effects are not fully defined. Herein, we evaluated the dual inflammatory response mechanism of adiponectin in macrophages. Short-term globular adiponectin (gAd) treatment induced IκBα degradation, NF-κB nuclear translocation, and TNF-α production in RAW 264.7 cells. Polymyxin B pretreatment did not block gAd-induced IκBα degradation, and heated gAd was unable to degrade IκBα, suggesting that the effects of gAd were not due to endotoxin contamination. gAd activated IKK and Akt, and inhibition of either IKK or Akt by dominant-negative IKKβ (DN-IKKβ) or DN-Akt overexpression blocked gAd-induced IκBα degradation, suggesting that short-term incubation with gAd mediates inflammatory responses by activating the IκB/NF-κB and PI3K/Akt pathways. Contrastingly, long-term stimulation with gAd induced, upon subsequent stimulation, tolerance to gAd, lipopolysaccharide, and CpG-oligodeoxynucleotide, which is associated with gAd-induced downregulation of IL-receptorassociated kinase-1 (IRAK-1) due to IRAK-1 transcriptional repression. Conclusively, our findings demonstrate that the pro- and anti-inflammatory responses to gAd in innate immune cells are time-dependent, and mediated by the activation of the IκB/NF-κB pathway, and IRAK-1 downregulation, respectively.
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참고문헌 (46)
참고문헌 신청
Ajuwon, K.M. / 2005 / Adiponectin inhibits LPSinduced NF-kappaB activation and IL-6 production and increases PPARgamma2 expression in adipocytes / Am. J. Physiol. Regul. Integr. Comp. Physiol. 288:R1220~R1225
Arita, Y. / 1999 / Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity / Biochem. Biophys. Res. Commun. 257:79~83
Berg, A.H. / 2001 / The adipocyte-secreted protein Acrp30 enhances hepatic insulin action / Nat. Med. 7:947~953
Chan, K.H. / 2010 / Elevated plasma adiponectin levels in patients with chronic obstructive pulmonary disease / Int. J. Tuberc. Lung Dis. 14:1193~1200
Chandra, R. / 2013 / IRAK1-dependent signaling mediates mortality in polymicrobial sepsis / Inflammation 36:1503~1512
Arita, Y. / 1999 / Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity / Biochem. Biophys. Res. Commun. 257:79~83
Berg, A.H. / 2001 / The adipocyte-secreted protein Acrp30 enhances hepatic insulin action / Nat. Med. 7:947~953
Chan, K.H. / 2010 / Elevated plasma adiponectin levels in patients with chronic obstructive pulmonary disease / Int. J. Tuberc. Lung Dis. 14:1193~1200
Chandra, R. / 2013 / IRAK1-dependent signaling mediates mortality in polymicrobial sepsis / Inflammation 36:1503~1512
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