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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 515 - 522 (8page)
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초록· 키워드
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Patients with head and neck cancer are treated with thera-peutic irradiation, which can result in irreversible salivary gland dysfunction. Because there is no complete cure for such patients, stem cell therapy is an emerging alternative for functional restoration of salivary glands. In this study, we investigated in vitro characteristics of primarily isolated epithelial cells from human salivary gland (Epi-SGs) and in vivo formation of acini-like structures by Epi-SGs. Primarily isolated Epi-SGs showed typical epithelial cell-like morphology and expressed E-cadherin but not N-cadherin. Epi-SGs expressed epithelial stem cell (EpiSC) and embryonic stem cell (ESC) markers. During long-term culture, the expression of EpiSC and ESC markers was highly detected and maintained within the core population with small size and low cytoplasmic complexity. The core population expressed cytokeratin 7 and cytokeratin 14, known as duct markers indicating that Epi-SGs might be originated from the duct. When Epi-SGs were transplanted in vivo with Matrigel, acini-like structures were readily formed at 4 days after transplan-tation and they were maintained at 7 days after transplantation. Taken together, our data suggested that Epi-SGs might contain stem cells which were positive for EpiSC and ESC markers, and Epi-SGs might contribute to the regeneration of acini-like struc-tures in vivo. We expect that Epi-SGs will be useful source for the functional restoration of damaged salivary gland.
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참고문헌 (25)
참고문헌 신청
Chen, Z. / 2004 / Characterization of putative stem cell phenotype in human limbal epithelia / Stem Cells 22:355~366
De Moerlooze, L. / 2000 / An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis / Development 127:483~492
de Paiva, C.S. / 2005 / ABCG2 transporter identifies a population of clonogenic human limbal epithelial cells / Stem Cells 23:63~73
Ema, H. / 2014 / Heterogeneity and hierarchy of hematopoietic stem cells / Exp. Hematol. 42:74~82
Feng, J. / 2009 / Isolation and characterization of human salivary gland cells for stem cell transplantation to reduce radiation-induced hyposalivation / Radiother. Oncol. 92:466~471
De Moerlooze, L. / 2000 / An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis / Development 127:483~492
de Paiva, C.S. / 2005 / ABCG2 transporter identifies a population of clonogenic human limbal epithelial cells / Stem Cells 23:63~73
Ema, H. / 2014 / Heterogeneity and hierarchy of hematopoietic stem cells / Exp. Hematol. 42:74~82
Feng, J. / 2009 / Isolation and characterization of human salivary gland cells for stem cell transplantation to reduce radiation-induced hyposalivation / Radiother. Oncol. 92:466~471
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