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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.2
- 수록면
- 103 - 109 (7page)
- DOI
- 10.14348/molcells.2018.2170
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초록· 키워드
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Calcium ions are involved in the regulation of diverse cellular processes. Fourteen genes encoding calcium binding proteins have been identified in Dictyostelium. CBP7, one of the 14 CBPs, is composed of 169 amino acids and contains four EF-hand motifs. Here, we investigated the roles of CBP7 in the development and cell migration of Dictyostelium cells and found that high levels of CBP7 exerted a negative effect on cells aggregation during development, possibly by inhibiting chemoattractant-directed cell migration. While cells lack-ing CBP7 exhibited normal development and chemotaxis similar that of wild-type cells, CBP7 overexpressing cells completely lost their chemotactic abilities to move toward increasing cAMP concentrations. This resulted in inhibition of cellular aggregation, a process required for forming multicellular organisms during development. Low levels of cytosolic free calcium were observed in CBP7 overexpressing cells, which was likely the underlying cause of their lack of chemotaxis. Our results demonstrate that CBP7 plays an important role in cell spreading and cell-substrate adhesion. cbp7 null cells showed decreased cell size and cell-substrate adhesion. The present study contributes to further understanding the role of calcium signaling in regulation of cell migration and development.
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참고문헌 (24)
참고문헌 신청
Andre, B. / 1996 / Dictyostelium discoideum contains a family of calmodulin-related EF-hand proteins that are developmentally regulated / FEBS Lett 382:198~202
Catalano, A. / 2013 / Rad53 homologue forkheadassociated kinase A (FhkA). and $Ca^{2+}$ -binding protein 4a (CBP4a) are nucleolar proteins that differentially redistribute during mitosis in Dictyostelium / Cell Div 8:4
Chin, D. / 2000 / Calmodulin: a prototypical calcium sensor / Trends Cell Biol 10:322~328
Chisholm, R.L. / 2004 / Insights into morphogenesis from a simple developmental system / Nat. Rev. Mol. Cell Biol. 5:531~541
Clapham, D.E / 2007 / Calcium signaling / Cell 131:1047~1058
Catalano, A. / 2013 / Rad53 homologue forkheadassociated kinase A (FhkA). and
Chin, D. / 2000 / Calmodulin: a prototypical calcium sensor / Trends Cell Biol 10:322~328
Chisholm, R.L. / 2004 / Insights into morphogenesis from a simple developmental system / Nat. Rev. Mol. Cell Biol. 5:531~541
Clapham, D.E / 2007 / Calcium signaling / Cell 131:1047~1058
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Proper Regulation of CBP7, a Calcium Binding Protein, is Required for Development in Dictyostelium
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