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논문 기본 정보

자료유형
학술저널
저자정보
Rodríguez-Morales Jahir (Neurosurgery Specialty Faculty of Medicine National Autonomous University of Mexico Mexico City 045) Guartazaca-Guerrero Sebastián (Neurosurgery Specialty Faculty of Medicine National Autonomous University of Mexico Mexico City 045) Rizo-Téllez Salma A. (Laboratory of Immunometabolism Research Division General Hospital of Mexico “Dr. Eduardo Liceaga” M) Viurcos-Sanabria Rebeca (Laboratory of Immunometabolism Research Division General Hospital of Mexico “Dr. Eduardo Liceaga” M) Barrón Eira Valeria (Genomic Medicine General Hospital of Mexico “Dr. Eduardo Liceaga” Mexico City 06720 Mexico) Hernández-Valencia Aldo F. (Unit for Stereotactic and Functional Neurosurgery General Hospital of Mexico Mexico City 06720 Mexi) Nava Porfirio (Departments of Physiology Biophysics and Neurosciences CINVESTAV-IPN Mexico City 07360 Mexico) Escobedo Galileo (Laboratory of Immunometabolism Research Division General Hospital of Mexico “Dr. Eduardo Liceaga” M) Carrillo-Ruiz José Damián (Unit for Stereotactic and Functional Neurosurgery General Hospital of Mexico Mexico City 06720 Mexi) Méndez-García Lucía A. (Laboratory of Immunometabolism Research Division General Hospital of Mexico “Dr. Eduardo Liceaga” M)
저널정보
한국뇌신경과학회 Experimental Neurobiology Experimental Neurobiology Vol.31 No.4
발행연도
2022.8
수록면
270 - 276 (7page)
DOI
10.5607/en21049

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Transsynaptic transport is the most accepted proposal to explain the SARS-CoV-2 infection of the CNS. Nevertheless, emerging evidence shows that neurons do not express the SARS-CoV-2 receptor ACE2, which highlights the importance of the blood-brain barrier (BBB) in preventing virus entry to the brain. In this study, we examine the presence of SARS-CoV-2 messenger ribonucleic acid (mRNA) and the cytokine profile in cerebrospinal fluids (CSF) from two patients with a brain tumor and COVID-19. To determine the BBB damage, we evaluate the Q- albumin index, which is an indirect parameter to assess the permeability of this structure. The Q-albumin index of the patient with an intraventricular brain tumor suggests that the BBB is undamaged, preventing the passage of SARS-CoV-2 and pro-inflammatory molecules. The development of brain tumors that disrupt the BBB (measured by the Q-albumin index), in this case, a petroclival meningioma (Case 1), allows the free passage of the SARS-CoV-2 virus and probably lets the free transit of pro-inflammatory molecules to the CNS, which leads to a possible activation of the microglia (astrogliosis) and an exacerbated immune response represented by IL-13, IFN-γ, and IL-2 trying to inhibit both the infection and the carcinogenic process.

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