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논문 기본 정보

자료유형
학술저널
저자정보
Lee Yesung (Department of Occupational and Environ mental Medicine Kangbuk Samsung Hospital School of Medicine) Lee Woncheol (Department of Occupational and Environ mental Medicine Kangbuk Samsung Hospital School of Medicine) 김형렬 (가톨릭대학교)
저널정보
한국역학회 Epidemiology and Health Epidemiology and Health Vol.44
발행연도
2022.1
수록면
1 - 10 (10page)
DOI
10.4178/epih.e2022104

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OBJECTIVES: Long working hours have been reported to cause various health problems. However, long working hours are currently practiced in many countries. To confirm the consistency with a previous study, the authors aimed to elucidate the causal relationship between long working hours and hypothyroidism through a longitudinal study. METHODS: Data was collected at baseline from 45,259 participants without thyroid disease and with no change in groups of weekly working hours, which were categorized into 36–40, 41–52, 53–60, and > 60 hours, during follow-up period. Hypothy roidism was defined using the reference limits of serum thyroid-stimulating hormone and free thyroxine levels. By estimating hazard ratios (HRs) and 95% confidence intervals (CIs) using Cox proportional hazards regression analyses, the risk of incident hypothyroidism was evaluated with weekly working 36–40 hours as the reference. RESULTS: During 138,261.7 person-years of follow-up, 2,914 participants developed hypothyroidism (incidence density, 2.11 per 102 person-years). Multivariable-adjusted HRs of incident hypothyroidism for weekly working 41–52, 53–60, and > 60 hours compared with the reference group were 1.13 (95% CI 1.03–1.24), 2.53 (95% CI, 2.17–2.95), and 2.57 (95% CI, 2.09– 3.15), respectively. In dose-response analyses, long working hours had an approximately linear relationship with the incidence of hypothyroidism. The risk of incident hypothyroidism in weekly working 53–60 and > 60 hours compared with the reference group were significantly higher among the older age group (≥ 36 years, stratified by median age), men, and daytime workers. CONCLUSIONS: This large-scale cohort study demonstrated the association between long working hours and the increased risk of incident hypothyroidism with a dose-response relationship.

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