지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Purpose : This study aimed to investigate the incidence and risk factors of vitreous hemorrhage in patients with atrial fibrillation (AF) using thrombolytic agents with long-term follow-up.
Methods : Patients diagnosed with AF between 2002 and 2006 were selected from the National Health Insurance Corporation database and followed-up from 2007 to 2013. To investigate the relationship between the use of antiplatelets (aspirin and cilostazol) and vitreous hemorrhage, patients were divided based on length of antiplatelet use (<1 year, 1~4 years, and ≥4 years).
Results : A total of 7,471 patients were enrolled. Ninety-eight patients developed vitreous hemorrhage, of which 25 patients were taking aspirin (<1 year: 9[36%] patients, 1~4 years: 9[36%] patients, and ≥4 years: 7[28%] patients). The hazard ratio for developing vitreous hemorrhage after taking aspirin for 1~4 years was 0.799 and for ≥4 years was 0.489. In addition, 13 patients who developed vitreous hemorrhage were taking cilostazol (<1 year: 7[53.8%] patients, 1~4 years: 4[30.8%] patients, and ≥4 years: 2[15.4%] patients). The hazard ratios for developing vitreous hemorrhage after taking cilostazol for 1~4 years and for ≥4 years were 0.757 and 1.202, respectively. The cumulative incidence of vitreous hemorrhage at 12-years follow-up was 4.6%.
Conclusion : Long-term follow-up of patients with AF revealed that the use of aspirin and cilostazol may increase the risk of vitreous hemorrhage. However, vitreous hemorrhage was found to be multifactorial because the frequency of diabetic mellitus and hypertension was high in patients with vitreous hemorrhage.
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