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논문 기본 정보

자료유형
학술저널
저자정보
Manju Chandran (Osteoporosis and Bone Metabolism Unit Department of Endocrinology Singapore General Hospital) John P.Bilezikian (Division of Endocrinology Vagelos College of Physicians and Surgeons Columbia University USA) Nurshazwani Mat Salleh (Department of Endocrinology Singapore General Hospital Singapore) Hao Ying (National Public Health and Epidemiology Unit National Centre for Infectious Diseases Singapore) Joel Lau (Department of Endocrine Surgery National University Hospital Singapore) James Lee (Department of Endocrine Surgery National University Hospital Singapore) Mechteld C. deJong (Department of Endocrine Surgery National University Hospital Singapore) Aye Chan Maung (Department of Endocrinology Ealing Hospital London North West Healthcare NHS Trust United Kingdom) Rajeev Parameswaran (Department of Endocrine Surgery National University Hospital Singapore)
저널정보
대한골다공증학회 Osteoporosis and Sarcopenia Osteoporosis and Sarcopenia Vol.8 No.1
발행연도
2022.3
수록면
11 - 16 (6page)
DOI
10.1016/j.afos.2022.03.004

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Objectives: We sought to assess the incidence of hungry bone syndrome (HBS) following para thyroidectomy (PTX) for primary hyperparathyroidism (PHPT) in a cohort of multi-ethnic patients from a developed country in the Asia Pacific. Methods: One hundred and sixty-four patients who underwent PTX for PHPT between 2012 and 2019 at the 2 largest public hospitals in Singapore were identified. HBS was defined as serum albumin-adjusted calcium ≤ 2.1 mmol/L with normal or raised serum intact parathyroid hormone (iPTH) levels, manifesting on or after the 3rd day, or persisting for more than 3 days post-operatively. Results: Chinese constituted 73.8%, Malays 12.2%, Indians 9.8%, and other races 4.3%. HBS developed in 4 patients (2.4%) (95% CI, 0.8%-6.5%). HBS patients had significantly longer in-hospital stays; 20 days [IQR:15-22] vs 2 days [IQR:1-3]; P < 0.001in those who did not develop HBS. There was no difference in the incidence of HBS stratifying for age, sex, vitamin D status, or use of preoperative anti-resorptive medication use. For every 10 unit increase in iPTH and alkaline phosphatase (ALP) levels, the risk of HBS increased by 14% and 11%; RR (95% CI), 1.14 (1.05-1.21) and 1.11 (1.03-1.18), respectively. Conclusions: The low incidence of HBS in multi-ethnic patients undergoing PTX by multiple surgeons for PHPT at the 2 largest public hospitals that see the most such patients in Singapore, a developed country, is consistent with the asymptomatic/milder form of presentation of PHPT in the developed world.

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